作者Zhao, Xuan;Wang, Lin;Wang, Li-Hong;Niu, Wen-Hui;Wang, Hao;Zhang, Han-Ting
（
aInstitute of Pharmacology, Shandong First Medical University, Shandong, Taian, 271016, China;bFirst People's Hospital of Jining City, Shandong, Jining, 272000, China;cChaoyang Campus of the 968th Hospital of the People's Liberation Army, Liaoning, Chaoyang, 122000, China;dSchool of Pharmacy, Nanchang University, Nanchang, 330019, China
）
出处
Chinese Pharmacological Bulletin 2026 Vol.42 No.2
P272-281
关键词
3×Tg-AD mice;Alzheimer’ s disease;apoptosis;cognitive dysfunction;roflumilast;Tau;
摘要
Aim This study aimed to evaluate the potential ameliorative effects of the phosphodiesterase 4 inhibitor roflumilaston cognitive function in the 3×Tg-
作者Mei Li;Nianzhuang Qiu;Wenhui Niu;Chenliang Qian;Yuqiong Zhang;Wubin Yang;Fengyang Ding;Hao Wang;Xiaoyan Xu;Jie Xia & …Xuehui Zhang
（
1School of Pharmaceutical Sciences, Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China;2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China;3Department of Neurobiology, School of Basic Medical Sciences, National Institute on Drug Dependence, Peking University, Beijing, 100191, China
）
摘要
Alzheimer’s disease is a neurodegenerative disorder characterized by the pathological accumulation of amyloid-β plaques and neurofibrillary tangles.
作者Wang, Hao;Zhang, Yan;Liu, Hong;Li, Guodong
（
aDepartment of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University, Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China
）
出处
Chinese Journal of Digestive Endoscopy 2025 Vol.42 No.8
P655-657
作者Yao, Yin;Chen, Zhian;Zhang, Hao;Chen Cailing;Zeng Ming;Yunis, Joseph;Wei Yunbo;Wan Yanmin;Wang Naiqi;Zhou, Mingzhe;Qiu, Chao;Zeng Qunxiong;Ong, Hong Sheng;Wang, Hao;Makota Fadzai Victor;Yang, Yang;Yang, Zhaohui;Wang, Nan;Deng, Jun;Shen, Chao;Xia, Yan;Lin, Yuan;Lian Zhaoqin;Deng Yike;Guo Cuilian;Huang Ao;Zhou, Pengcheng;Shi, Haibo;Zhang Weitian;Yi Hongliang;Li, Dongmei;Xia Ming;Fu, Jing;Wu, Ning;de Haan Judy B;Shen, Nan;Zhang, Wenhong;Liu, Zheng;Yu, Di
（
1 Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Department of Otolaryngology-Head and Neck Surgery, Wuhan, China (GRID:grid.412793.a) (ISNI:0000 0004 1799 5032); The University of Queensland, The University of Queensland Diamantina Institute, Faculty of Medicine, Brisbane, Australia (GRID:grid.1003.2) (ISNI:0000 0000 9320 7537); Australian National University, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Canberra, Australia (GRID:grid.1001.0) (ISNI:0000 0001 2180 7477) 2 The University of Queensland, The University of Queensland Diamantina Institute, Faculty of Medicine, Brisbane, Australia (GRID:grid.1003.2) (ISNI:0000 0000 9320 7537); Australian National University, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Canberra, Australia (GRID:grid.1001.0) (ISNI:0000 0001 2180 7477) 3 Qilu University of Technology (Shandong Academy of Sciences), Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Jinan, China (GRID:grid.443420.5) (ISNI:0000 0000 9755 8940); Minda Hospital of Hubei Minzu University, Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Enshi, China (GRID:grid.508104.8) 4 Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Department of Otolaryngology-Head and Neck Surgery, Wuhan, China (GRID:grid.412793.a) (ISNI:0000 0004 1799 5032) 5 Qilu University of Technology (Shandong Academy of Sciences), Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Jinan, China (GRID:grid.443420.5) (ISNI:0000 0000 9755 8940) 6 Huashan Hospital, Fudan University, Department of Infectious Diseases, Shanghai, China (GRID:grid.411405.5) (ISNI:0000 0004 1757 8861); Fudan University, Department of Radiology, Shanghai Public Health Clinical Center, Shanghai, China (GRID:grid.8547.e) (ISNI:0000 0001 0125 2443) 7 The University of Queensland, The University of Queensland Diamantina Institute, Faculty of Medicine, Brisbane, Australia (GRID:grid.1003.2) (ISNI:0000 0000 9320 7537) 8 Simcere Diagnostics Co., Ltd., State Key Laboratory of Translational Medicine and Innovative Drug Development, Nanjing, China (GRID:grid.495450.9) (ISNI:0000 0004 0632 5172) 9 Minhang Hospital and Huashan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China (GRID:grid.8547.e) (ISNI:0000 0001 0125 2443) 10 Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, China–Australia Centre for Personalised Immunology, Shanghai, China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293) 11 Australian National University, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Canberra, Australia (GRID:grid.1001.0) (ISNI:0000 0001 2180 7477) 12 Minda Hospital of Hubei Minzu University, Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Enshi, China (GRID:grid.508104.8) 13 Minda Hospital of Hubei Minzu University, Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Enshi, China (GRID:grid.508104.8); Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, China–Australia Centre for Personalised Immunology, Shanghai, China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293) 14 Wuhan University, State Key Laboratory of Virology, College of Life Sciences, Wuhan, China (GRID:grid.49470.3e) (ISNI:0000 0001 2331 6153) 15 Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Department of Otolaryngology-Head and Neck Surgery, Shanghai, China (GRID:grid.412528.8) (ISNI:0000 0004 1798 5117) 16 Qilu Children’s Hospital of Shandong University, Department of Otolaryngology, Jinan, China (GRID:grid.27255.37) (ISNI:0000 0004 1761 1174) 17 Shandong Provincial Hospital Affiliated to Shandong First Medical University, Key Laboratory for Hearing Reconstruction of Shandong Province, Department of Otolaryngology, Jinan, China (GRID:grid.460018.b) (ISNI:0000 0004 1769 9639) 18 Monash University, Department of Mechanical and Aerospace Engineering, Melbourne, Australia (GRID:grid.1002.3) (ISNI:0000 0004 1936 7857) 19 Huazhong University of Science and Technology, Department of Immunology, School of Basic Medicine, Tongji Medical College, Wuhan, China (GRID:grid.33199.31) (ISNI:0000 0004 0368 7223) 20 Monash University, Baker Heart and Diabetes Institute, Melbourne, Australia (GRID:grid.1002.3) (ISNI:0000 0004 1936 7857) 21 Huashan Hospital, Fudan University, Department of Infectious Diseases, Shanghai, China (GRID:grid.411405.5) (ISNI:0000 0004 1757 8861) 22 The University of Queensland, The University of Queensland Diamantina Institute, Faculty of Medicine, Brisbane, Australia (GRID:grid.1003.2) (ISNI:0000 0000 9320 7537); Australian National University, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Canberra, Australia (GRID:grid.1001.0) (ISNI:0000 0001 2180 7477); Qilu University of Technology (Shandong Academy of Sciences), Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Jinan, China (GRID:grid.443420.5) (ISNI:0000 0000 9755 8940); Minda Hospital of Hubei Minzu University, Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Enshi, China (GRID:grid.508104.8); Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, China–Australia Centre for Personalised Immunology, Shanghai, China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293)
）
作者Qiu, Nian-zhuang;Hou, Hui-mei;Guo, Tian-yang;Lv, Yu-li;zhou, Yao;Zhang, Fang-fang;Zhang, Feng;Wang, Xiao-dan;Chen, Wei;Gao, Yong-feng;Chen, Mei-hua;Zhang, Xue-hui;Zhang, Han-ting;Wang, Hao
（
1 Shandong First Medical University & Shandong Academy of Medical Sciences, Institute of Pharmacology, Tai’an, China (GRID:grid.410587.f) 2 Shandong First Medical University & Shandong Academy of Medical Sciences, Development Planning and Discipline Construction Department, Tai’an, China (GRID:grid.410587.f) 3 Shandong First Medical University & Shandong Academy of Medical Sciences, Institute of Pharmacology, Tai’an, China (GRID:grid.410587.f); Qingdao University School of Pharmacy, Department of Pharmacology, Qingdao, China (GRID:grid.410645.2) (ISNI:0000 0001 0455 0905)
）
出处
Neurochemical Research 2024 Vol.49 No.8
P1993-2004
摘要
Phosphodiesterase 8 , as a member of PDE superfamily, specifically promotes the hydrolysis and degradation of intracellular cyclic adenosine monophosp
作者Zhen-nan Yuan;Yu-juan Xue;Da-wei Li;Hong-sheng Ji;Hai-jun Wang;Fang Cao;Shi-ning Qu;Chu-lin Huang;Hao Wang;Hao Zhang;null;Xue-zhong Xing
（
1Department of Intensive Care Unit, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China;2Department of Pediatrics, Peking University People’s Hospital, Peking University, Beijing, China;3Department of the Intensive Care Unit, The Sixth Medical Center of the PLA General Hospital, Beijing, China;4Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwuweiqi Road, Jinan, 250021, Shandong, China
）
摘要
The design of this study is to compare the effectiveness of two analgesic drugs in the intervention of pain events for patients on mechanical ventilat
摘要
The shortcomings of precious metal based catalysts have limited the development of novel energies. So, developing low-cost and high performance transi
作者Hao Wang;Hongna Yang
（
1Department of Critical Care Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong 250012, China;2Department of Critical Care Medicine, Shandong Province Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, Shandong 250021, China
）
摘要
Tropheryma whipplei is extensively known as the etiological bacterium of Whipple’s disease . Here, we reported a case of community-acquired pneumonia
作者Hao Wang;Hongna Yang
（
1Department of Critical care medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China;2Department of Critical care medicine, Shandong Province Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, Shandong, 250021, China
）
摘要
Tropheryma whipplei is extensively known as the etiological bacterium of Whipple’s disease . Here, we reported a case of community-acquired pneumonia
摘要
The shortcomings of precious metal based catalysts have limited the development of novel energies. So, developing low-cost and high performance transi
