Copper(II)-catalyzed remote sulfonylation of aminoquinolines with sodium sulfinates via radical coupling

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作者: Chengcai Xia* Kai Wang Jun Xu Zhenjiang Wei Chao Shen Guiyun Duan Qing Zhu and Pengfei Zhang*

作者单位: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China a Pharmacy College, Taishan Medical University, Tai’an 271016, China E-mail: chxyzpf@hotmail.com Fax: +86-571-28862867 Tel: +86-571-28862867 College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China College of Biology and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China

摘要: The efficient remote sulfonylation of N-(quinolin-8-yl)benzamide derivatives at the C5 position has been well developed. The reaction generates environmentally benign byproducts by utilizing stable and safe sodium sulfinates as sulfide sources. A series of N-(5-(phenylsulfonyl)quinolin-8-yl)benzamide derivatives were successfully obtained in moderate to high yields. In particular, they are less unpleasantly odorous and more environmentally friendly than previous means.

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