Effects of ACEI and low sodium intake on the renin-angiotensin system in mice with unilateral hydronephrosis

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摘要: Objective Administration of ACE inhibitor (ACEI) and low sodium intake (LSI) increase plasma renin concentration. However, it is not clearly understood how ACEI and LSI alter both renin release and synthesis. The aim of this study was to determine the role of ACEI and LSI in both renin expression and release in hydronephrotic mice. Methods Balb/C mice (25–30 g) were anesthetized with sodium pentobarbitone (60 mg kg−1, i.p.) and the left ureter was ligated except sham-operated animals. Four weeks...更多; Objective Administration of ACE inhibitor (ACEI) and low sodium intake (LSI) increase plasma renin concentration. However, it is not clearly understood how ACEI and LSI alter both renin release and synthesis. The aim of this study was to determine the role of ACEI and LSI in both renin expression and release in hydronephrotic mice. Methods Balb/C mice (25–30 g) were anesthetized with sodium pentobarbitone (60 mg kg−1, i.p.) and the left ureter was ligated except sham-operated animals. Four weeks later, the left kidney became hydronephrotic.收起

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