Crystal Structure and Activity against Acetaminophen-induced Hepatotoxicity of a Potassium Complex with Taurine-5-bromosalicylaldehyde Schiff Bases

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作者单位: College of Pharmacy, Dalian Medical University, Dalian 116044, China Department of Chemistry, Taishan University, Shandong 271021, China Department of Chemistry, Taishan University, Shandong 271021, China College of Pharmacy, Dalian Medical University, Dalian 116044, China College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116001, China

摘要: A novel potassium complex KC9H9NO4SBr has been synthesized and charac-terized by IR spectra and single-crystal X-ray diffraction method. The crystal belongs to orthor-hombic, space group Pbca with a=0.74040, b=0.74960, c=4.2620 nm, V= 2.3654 nm3, Mr = 346.24, Dc = 1.945 g/cm3, Z= 8, F = 1376, μp = 4.005mm-1, GOOF= 1.021, R = 0.0471 and wR = 0.0872. In the crystal, the potassium ion is typically eight-coordinated, surrounded by eight O atoms from six -2-ethane-sulfonate anions. The neighboring po...更多; A novel potassium complex KC9H9NO4SBr has been synthesized and charac-terized by IR spectra and single-crystal X-ray diffraction method. The crystal belongs to orthor-hombic, space group Pbca with a=0.74040, b=0.74960, c=4.2620 nm, V= 2.3654 nm3, Mr = 346.24, Dc = 1.945 g/cm3, Z= 8, F = 1376, μp = 4.005mm-1, GOOF= 1.021, R = 0.0471 and wR = 0.0872. In the crystal, the potassium ion is typically eight-coordinated, surrounded by eight O atoms from six -2-ethane-sulfonate anions. The neighboring potassium ions are bridged by sulfonate groups into a two-dimensional layer structure, above and below which the 5-bromo-2-hydroxy-benzene rings are protruded. The activity against acetaminophen-indueed hepatotoxieity of this complex was also studied, and found it can protect liver from hepatotoxieity induced by acetaminophen to some extent.收起

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