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作者

Kai Meng Bo Wu Jing Gao Yumei Cai Meiling Yao Liangmeng Wei and Tongjie Chai

作者单位

Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, College of Veterinary Medicine, Shandong Agricultural University, Tai’an, China Collaborative Innovation Centre for the Origin and Control of Emerging Infectious Diseases, Taishan Medical College, Tai’an, China Zaozhuang Vocational College, Shandong, China Taian Central Hospital, Tai’an, China

刊名

Frontiers in Immunology

年份

2016

卷号

Vol.7

页码

252

关键词

particulate matter biological material live bird market immunity-related protein lung injury

分类号

616.07

摘要

The objective of this study was to obtain insight into the adverse health effects of airborne particulate matter collected from live bird markets and to determine whether biological material in PM accounts for immune-related inflammatory response. Mice were exposed to a single or repeated dose of PM, after which the expression of toll-like receptors , cytokines, and chemokines in the lungs of infected mice were examined by enzyme-linked immunosorbent assay and histopathological analysis. Result...更多

The objective of this study was to obtain insight into the adverse health effects of airborne particulate matter collected from live bird markets and to determine whether biological material in PM accounts for immune-related inflammatory response. Mice were exposed to a single or repeated dose of PM, after which the expression of toll-like receptors , cytokines, and chemokines in the lungs of infected mice were examined by enzyme-linked immunosorbent assay and histopathological analysis. Results after single and repeated PM stimulation with PM 2 . 5 + , PM 2 . 5 − , PM 10 + ,  and PM 10 − indicated that TLR2 and TLR4 played a dominant role in the inflammatory responses of the lung. Further analysis demonstrated that the expression levels of IL-1β, TNF-α, IFN-γ, IL-8, IP-10, and MCP-1 increased significantly, which could eventually contribute to lung injury. Moreover, biological components in PM were critical in mediating immune-related inflammatory responses and should therefore not be overlooked.收起

学科

【SCI学科】IMMUNOLOGY

文献类型

期刊

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