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作者

Zheng X Zeng N Wang A Zhu Z Zhong C Xu T Peng Y Peng H Li Q Ju Z Geng D Zhang Y He J

作者单位

Department of Neurology, Affiliated Hospital of North China University of Science and Technology, Hebei. China. Department of Neurology, Kerqin District First People's Hospital of Tongliao City, Inner Mongolia. China. Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Jiangsu. China. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA. American Samoa. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou. China. Department of Epidemiology, School of Public Health, Taishan Medical College, Shandong. China.

刊名

Current Neurovascular Research

年份

2018

ISSN

1567-2026

关键词

C-reactive protein high-density lipoprotein cholesterol stroke

分类号

616.8

摘要

Aims: C-reactive protein is an established marker of inflammation that can impair the protective function of high density lipoprotein cholesterol . The combined effect of C-reactive protein and HDL-C on long-term outcomes in patients with stroke remains uncertain. Methods: A total of 3124 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke were included in this analysis. Participants were divided into four groups according to CRP and HDL-C levels on adm...更多

Aims: C-reactive protein is an established marker of inflammation that can impair the protective function of high density lipoprotein cholesterol . The combined effect of C-reactive protein and HDL-C on long-term outcomes in patients with stroke remains uncertain. Methods: A total of 3124 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke were included in this analysis. Participants were divided into four groups according to CRP and HDL-C levels on admission. The primary outcome was a combination of death and major disability at one year after stroke. Results: Compared to participants with low CRP/ high HDL-C, adjusted odd ratios for primary outcome for those with low CRP /low HDL-C, high CRP /high HDL-C and high CRP /low HDL-C were 1.06,1.78 and 2.03, respectively, after multiple adjustments. Adding serum CRP and HDL-C status to a model containing conventional stroke risk factors significantly improve risk reclassification for the combined outcome of death and major disability .Moreover, no interaction was observed between CRP and HDL-C in relation to stroke outcomes . Conclusions: High CRP with low HDL-C levels was associated with death and major disability within one year after ischemic stroke. The findings suggest that the ischemic patients with both high CRP and low HDL-C should be treated with reducing CRP and promoting HDL-C levels.收起

学科

【SCI学科】CLINICAL NEUROLOGY;NEUROSCIENCES 【ESI学科】NEUROSCIENCE & BEHAVIOR

影响因子

2016年:2.298;2015年:2.123;2014年:2.253;2013年:2.735;2012年:2.844

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期刊

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11