Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses.

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作者单位: Taishan Med Coll, Inst Pathogen Biol, Tai An, Shandong, Peoples R China Nanjing Agr Univ, Inst Immunol, Engn Lab Anim Immun Jiangsu Prov, Nanjing, Jiangsu, Peoples R China Chinese Acad Sci, CAS Ctr Influenza Res & Early Warning CASCIRE, Beijing, Peoples R China Kentucky State Univ, Frankfort, KY USA Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China [ 10 ] Univ Chinese Acad Sci, Chinese Acad Sci, Sch Med, Beijing, Peoples R China Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen, Peoples R China Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China

摘要: Human coronaviruses (HCoVs) were first described in the 1960s for patients with the common cold. Since then, more HCoVs have been discovered, including those that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), two pathogens that, upon infection, can cause fatal respiratory disease in humans. It was recently discovered that dromedary camels in Saudi Arabia harbor three different HCoV species, including a dominant MERS HCoV lineage that was responsible ...更多; Human coronaviruses (HCoVs) were first described in the 1960s for patients with the common cold. Since then, more HCoVs have been discovered, including those that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), two pathogens that, upon infection, can cause fatal respiratory disease in humans. It was recently discovered that dromedary camels in Saudi Arabia harbor three different HCoV species, including a dominant MERS HCoV lineage that was responsible for the outbreaks in the Middle East and South Korea during 2015. In this review we aim to compare and contrast the different HCoVs with regard to epidemiology and pathogenesis, in addition to the virus evolution and recombination events which have, on occasion, resulted in outbreaks amongst humans.收起

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