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作者

Bi, YH Chen, QJ Wang, QL Chen, JJ Jin, T Wong, G Quan, CS Liu, J Wu, J Yin, RF

作者单位

Chinese Acad Sci, Inst Microbiol, Collaborat Innovat Ctr Diag & Treatment Infect Di, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China BGI Shenzhen, China Natl Genebank Shenzhen, Shenzhen 518083, Peoples R China Jilin Univ, Coll Vet Med, Dept Vet Prevent Med, Changchun 130062, Jilin, Peoples R China Diqing Tibetan Autonomous Prefecture Ctr Dis Cont, Shangri La 674400, Peoples R China [ 10 ] Natl Res Ctr Vet Med, Luoyang 471003, Peoples R China [ 11 ] Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350003, Peoples R China [ 12 ] Novosibirsk State Univ, Res Inst Expt & Clin Med, Novosibirsk 630090, Russia [ 13 ] South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China [ 14 ] Tsinghua Univ, Ctr Earth Syst Sci, Key Lab Earth Syst Modelling, Minist Educ, Beijing 100084, Peoples R China [ 15 ] Chinese Ctr Dis Control & Prevent, Key Lab Surveillance & Early Warning Infect Dis, Div Infect Dis, Beijing 102206, Peoples R China [ 16 ] Guangxi Univ, Coll Anim Sci & Vet Med, Lab Anim Infect Dis, Nanning 530004, Peoples R China [ 17 ] Taishan Med Coll, Inst Pathogen Biol, Tai An 271016, Shandong, Peoples R China [ 18 ] Chinese Acad Sci, Inst Microbiol, Network Informat Ctr, Beijing 100101, Peoples R China [ 19 ] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA [ 20 ] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China Yunnan Ctr Dis Control & Prevent, Kunming 650022, Peoples R China Shenzhen Third Peoples Hosp, State Key Discipline Infect Dis, Shenzhen Key Lab Pathogen & Immun, Shenzhen 518112, Peoples R China

刊名

Cell Host Microbe

年份

2016

卷号

Vol.20 No.6

页码

810-821

ISSN

1931-3128

关键词

H5N6 avian influenza birds evolution genesis human infection live poultry markets prevalence resassortment

分类号

579

摘要

Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ...更多

Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.收起

影响因子

2016年:14.946;2015年:12.552;2014年:12.328;2013年:12.194;2012年:12.609

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期刊

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