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作者

Dong, MF Ma, ZS Ma, SJ Chai, SD Tang, PZ Yao, DK Wang, LX

作者单位

Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing, Peoples R China   增强组织信息的名称     Capital Medical University Liaocheng Peoples Hosp, Dept Cardiac Surg, Liaocheng 252000, Shandong, Peoples R China        Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2650, Australia   增强组织信息的名称     Charles Sturt University Taishan Med Univ, Liaocheng Clin Sch, Liaocheng 252000, Shandong, Peoples R China   增强组织信息的名称     Taishan Medical University

刊名

Thrombosis Research

年份

2011

卷号

Vol.128 No.5

页码

e91-e94

ISSN

0049-3848

关键词

INTENSITY ANTICOAGULATION BLEEDING COMPLICATIONS ANTIPLATELET THERAPY PLATELET-FUNCTION METAANALYSIS DISEASE MANAGEMENT TRIALS RISK

分类号

616.1

摘要

Introduction: This study was designed to evaluate safety and efficacy of combined low dose aspirin and warfarin therapy following mechanical heart valve replacement. Methods: A total of 1496 patients (686 males, mean age 35±8.5 years) undergoing mechanical heart valvular replacement were randomly divided into study (warfarin plus 75-100 mg aspirin) or control (warfarin only) group. International normalized ratio (INR) and prothrombin time was maintained at 1.8-2.5 and 1.5-2.0 times of the normal...更多

Introduction: This study was designed to evaluate safety and efficacy of combined low dose aspirin and warfarin therapy following mechanical heart valve replacement. Methods: A total of 1496 patients (686 males, mean age 35±8.5 years) undergoing mechanical heart valvular replacement were randomly divided into study (warfarin plus 75-100 mg aspirin) or control (warfarin only) group. International normalized ratio (INR) and prothrombin time was maintained at 1.8-2.5 and 1.5-2.0 times of the normal value, respectively. Thromboembolic events and major bleedings were registered during follow up. Results: Patients were followed up for 24±9 months. The average dose of warfarin in the study and control group was 2.92±0.87 mg and 2.89±0.79 mg, respectively (p>0.05). The overall thromboembolic events in study group were lower than in control group (2.1% vs. 3.6%, p=0.044). No statistically significant differences were found in hemorrhage events (3.5% vs. 3.7%, p>0.05) or mortality (0.3% vs 0.4%, p>0.05) between the two groups. Conclusions: Following mechanical valve replacement, combined low dose aspirin and warfarin therapy was associated with a greater reduction in thromboembolism events than warfarin therapy alone. This combined treatment was not associated with an increase in the rate of major bleeding or mortality. (Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.)收起

学科

【SCI学科】PERIPHERAL VASCULAR DISEASE;HEMATOLOGY 【ESI学科】CLINICAL MEDICINE

影响因子

2016年:2.65;2015年:2.32;2014年:2.447;2013年:2.427;2012年:3.133

文献类型

期刊

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