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作者

Zhang, JG Zhang, F Qiu, YL Yue, W

作者单位

       Taishan Med Univ, Dept Pharmacol, Tai An 271016, Shandong, Peoples R China   增强组织信息的名称     Taishan Medical University Qingdao Univ Med Sch, Dept Pharmacol, Qingdao 266021, Shandong, Peoples R China

刊名

NEURAL REGENERATION RESEARCH

年份

2011

卷号

Vol.6 No.26

页码

2022-2025

ISSN

1673-5374

关键词

MEDIUM SPINY NEURONS PALLIDAL NEURONS BCL-2

分类号

616.8

摘要

The present study observed the action of (1)H-indole-2, 3-dione (isatin) on Box protein expression in the substantia nigra of a Parkinson\'s disease animal model. Parkinson\'s disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Box protein expression was significantly reduced in isatin (100, 200 mg/kg)-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax...更多

The present study observed the action of (1)H-indole-2, 3-dione (isatin) on Box protein expression in the substantia nigra of a Parkinson\'s disease animal model. Parkinson\'s disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Box protein expression was significantly reduced in isatin (100, 200 mg/kg)-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax protein expression.收起

学科

【SCI学科】CELL BIOLOGY;NEUROSCIENCES 【ESI学科】NEUROSCIENCE & BEHAVIOR

影响因子

2016年:1.769;2015年:0.968;2014年:0.22;2013年:0.234;2012年:0.144

文献类型

期刊

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