Isatin decreases Bax protein expression in the substantia nigra of a mouse model of Parkinson\'s disease

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作者单位: Taishan Med Univ, Dept Pharmacol, Tai An 271016, Shandong, Peoples R China 增强组织信息的名称 Taishan Medical University Qingdao Univ Med Sch, Dept Pharmacol, Qingdao 266021, Shandong, Peoples R China

摘要: The present study observed the action of (1)H-indole-2, 3-dione (isatin) on Box protein expression in the substantia nigra of a Parkinson\'s disease animal model. Parkinson\'s disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Box protein expression was significantly reduced in isatin (100, 200 mg/kg)-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax...更多; The present study observed the action of (1)H-indole-2, 3-dione (isatin) on Box protein expression in the substantia nigra of a Parkinson\'s disease animal model. Parkinson\'s disease-like behaviors were induced in C57BL/6J mice treated with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Box protein expression was significantly reduced in isatin (100, 200 mg/kg)-pretreated mice. Results demonstrate that isatin plays a neuroprotective role in mice treated with MPTP by down-regulating Bax protein expression.收起

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