Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW, Australia 增强组织信息的名称 Charles Sturt UniversityTaishan Med Univ, Dept Pharm, Liaocheng Peoples Hosp, Tai An, Shandong, Peoples R China 增强组织信息的名称 Taishan Medical UniversityTaishan Med Univ, Liaocheng Clin Sch, Tai An, Shandong, Peoples R China 增强组织信息的名称 Taishan Medical UniversityTaishan Med Univ, Dept Endocrinol, Liaocheng Peoples Hosp, Tai An, Shandong, Peoples R China 增强组织信息的名称 Taishan Medical University
Introduction: This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes. Materials and methods: Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. Testosterone was determined by the radio-immunoassay\' whereas adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). Results:The average serum testosterone did not dif...更多
Introduction: This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes. Materials and methods: Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. Testosterone was determined by the radio-immunoassay\' whereas adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). Results:The average serum testosterone did not differ between the diabetes and the control group, but the average adiponectin in the diabetes group was lower (14.6 (14.2-15.0) vs. 24.3 (24.05-24.55) ng/mL, P = 0.001). In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P 0.009). Univariate correlation analysis showed an inverse weak correlation between adiponectin and testosterone concentrations in male diabetic patients (r = -0.27, P = 0.009). There was no significant correlation between adiponectin and testosterone in female patients (r 0.05,P = 0.167). Conclusions: We conclude that patients with type 2 diabetes have lower serum adiponectin concentration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics.收起
