获取途径

作者

Bi, YH Mei, K Shi, WF Liu, D Yu, XL Gao, ZM Zhao, LH Gao, GF Chen, JJ Chen, QJ

作者单位

Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China Chinese Acad Sci, CAS Key Lab Pathogen Microbiol & Immunol CASPMI, Inst Microbiol, Beijing 100101, Peoples R China Chinese Ctr Dis Control & Prevent China CDC, Off Director Gen, Beijing 102206, Peoples R China Chinese Acad Sci, CAS Key Lab Special Pathogens & Biosafety, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China Hubei Univ, Wuhan 430062, Hubei, Peoples R China Taishan Med Coll, Inst Pathogen Biol, Shandong 271016, Peoples R China

刊名

The Journal of General Virology

年份

2015

卷号

Vol.96 Part 5

页码

975-981

摘要

Eight avian influenza A(H5N6) viruses were isolated from live poultry markets (LPMs) in Sichuan and Jiangxi Provinces in 2014, including those close to the country where the human H5N6 infection occurred. Genetic and phylogenetic analyses revealed that these H5N6 viruses are novel reassortants between H5N1 clade 2.3.4 and H6N6 viruses, and have evolved into two distinct lineages (Sichuan and Jiangxi). Moreover, the human-H5N6 virus was closely related to the avian-source viruses of Sichuan linea...更多

Eight avian influenza A(H5N6) viruses were isolated from live poultry markets (LPMs) in Sichuan and Jiangxi Provinces in 2014, including those close to the country where the human H5N6 infection occurred. Genetic and phylogenetic analyses revealed that these H5N6 viruses are novel reassortants between H5N1 clade 2.3.4 and H6N6 viruses, and have evolved into two distinct lineages (Sichuan and Jiangxi). Moreover, the human-H5N6 virus was closely related to the avian-source viruses of Sichuan lineage, Notably, H5N6 viruses contained a T160A substitution in the HA protein and an 11-amino acid-deletion in the NA stalk, which may aid in enhancing viral affinity for human-like receptors, and virulence in mammals. As the H5N1 virus infects humans through direct contact, infection with the novel H5N6 virus raises significant concerns that the H5 subtype is a likely candidate for a pandemic. Therefore, extensive and long-term surveillance of avian influenza viruses (AIVs) in LPMs is essential.收起

影响因子

2016年:2.838;2015年:3.192;2014年:3.183;2013年:3.529;2012年:3.127

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期刊

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