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作者

Liu, JY Sun, YL Shi, WF Tan, SG Pan, Y Cui, SJ Zhang, QC Dou, XF Lv, YN Li, XY

作者单位

Taishan Med Coll, Inst Pathogen Biol, Tai An 271000, Shandong, Peoples R China Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China Chinese Acad Sci, Key Lab Pathogen Microbiol & Immunol, Inst Microbiol, Beijing 100101, Peoples R China Capital Med Univ, Beijing Ditan Hosp, Beijing 100015, Peoples R China Beijing Ctr Dis Prevent & Control, Inst Infect Dis & Endem Dis Control, Beijing 100013, Peoples R China

刊名

Emerg Microbes Infect

年份

2017

卷号

Vol.6 No.1

页码

e4

ISSN

2222-1751

关键词

hypercytokinemia imported case reassortment Rift Valley fever virus

摘要

We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the le...更多

We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved. Whole-genome sequencing and phylogenetic analysis revealed that the imported strain was a reassortant comprising the L and M genes from lineage E and the S gene from lineage A. This case highlights that RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks and pose a serious threat to global public health as well as the livestock breeding industry.收起

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