Three antibacterial naphthoquinone analogues from cultured mycobiont of lichen Astrothelium sp

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作者单位: Shandong Normal Univ, Coll Life Sci, Jinan 250014, Peoples R China 增强组织信息的名称 Shandong Normal University Taishan Med Univ, Coll Pharmacol, Tai An 271016, Shandong, Peoples R China 增强组织信息的名称 Taishan Medical University Taishan Med Univ, Coll Chem & Chem Engn, Tai An 271016, Shandong, Peoples R China 增强组织信息的名称 Taishan Medical University Chinese Acad Sci, Key Lab Systemat Mycol & Lichenol, Inst Microbiol, Beijing 100101, Peoples R China 增强组织信息的名称 Institute of Microbiology, CAS Chinese Academy of Sciences

摘要: A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 was isolated from cultured mycobiont of Astrothelium sp. The structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as comparison with those reported in literatures. Compound 1 displayed significant antibacterial activity against Bacillus subtilis (ATCC 6633), and showed modest antibacterial activity against Staphylococcus au...更多; A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 was isolated from cultured mycobiont of Astrothelium sp. The structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as comparison with those reported in literatures. Compound 1 displayed significant antibacterial activity against Bacillus subtilis (ATCC 6633), and showed modest antibacterial activity against Staphylococcus aureus col (MRSA) (CGMCC 1.2465), while compounds 2 and 3 showed modest antibacterial activity against Enterococcus faecalis 850E (CGMCC 1.2135) and S. aureus col (MRSA) (CGMCC 1.2465).收起

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