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作者

Sun BL Zhang SM Xia ZL Yang MF Yuan H Zhang J Xiu RJ

作者单位

Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Neurol, Wuhan 430030, Peoples R China Chinese Acad Med Sci, Inst Microcirculat, Beijing 100005, Peoples R China Taishan Med Coll, Affiliated Hosp, Inst Microcirculat, Shandong 271000, Peoples R China

刊名

Clinical hemorheology and microcirculation

年份

2003

卷号

Vol.29 No.3/4

关键词

Body Water Brain Chemistry Calcium Channel Blockers Cations Cerebrovascular Circulation 身体水份 脑化学 钙通道阻滞药 阳离子 脑血管循环 尼莫地平 蛛网膜下腔出血

分类号

616.15

摘要

Secondary cerebral ischemic injury is a major cause of mortality and disability from subarachnoid hemorrhage . In this study, the protective effects of nimodipine were investigated. Rat SAH models were divided into a sham-operated group, a saline-controlled, and a nimodipine-treated group by an endovascular piercing method. Nimodipine, 100 microg/kg BW was injected intraperitoneally 30 minutes before operation and was repeated every 6 hours. Dynamic changes in cortical regional cerebral blood fl...更多

Secondary cerebral ischemic injury is a major cause of mortality and disability from subarachnoid hemorrhage . In this study, the protective effects of nimodipine were investigated. Rat SAH models were divided into a sham-operated group, a saline-controlled, and a nimodipine-treated group by an endovascular piercing method. Nimodipine, 100 microg/kg BW was injected intraperitoneally 30 minutes before operation and was repeated every 6 hours. Dynamic changes in cortical regional cerebral blood flow using a laser Doppler flow-meter probe, and somatosensory evoked potentials were estimated. Brain water content, sodium, potassium and calcium contents at different time points were determined. rCBF, latency of SEP, brain water and electrolyte contents did not statistically change in sham-operated rats. In saline-controlled rats, rCBF decreased immediately after SAH, and stabilized at low levels within 24 hours. The latency of SEP delayed gradually after SAH. Brain water and sodium increased, while potassium decreased at 6 hours and 24 hours. Brain calcium content increased significantly from 1 hour to 24 hours after induction of SAH. Extents of alterations of the above parameters caused by SAH in the nimodipine-treated group were less than those in the saline-controlled group, statistically. In conclusion, nimodipine partly prevents a decrease in cerebral blood supply and attenuates secondary cerebral ischemic injury after SAH.收起

学科

【SCI学科】PERIPHERAL VASCULAR DISEASE;HEMATOLOGY 【ESI学科】CLINICAL MEDICINE

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