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作者

Fenglian Zheng Yulin Liu Zilong Yuan Xiaodong Gao Yaoyao He Xiaojing Liu Dong Cui Rui Qi Tiao Chen Jianfeng Qiu

作者单位

Center for Medical Engineer Technology Research, Taishan Medical University, Taian, China Radiology of Department, Hubei Cancer Hospital, Wuhan, China Radiology of Department, Taishan Medical University, Taian, China

刊名

Journal of Magnetic Resonance Imaging

关键词

cortical subcortical deep gray matter nuclei hippocampal subfields

分类号

616.07

摘要

Background Cerebral structures in both cortical and subcortical regions change with aging. More specific and comprehensive studies are needed to better elucidate these changes. PURPOSE To investigate the relationships between age and cerebral structures regarding cortical and subcortical changes. Study Type Cross‐cohort research. Population 54 healthy adults aged 21–71 years. Field Strength/Sequence T 1 ‐weighted imaging was performed at 1.5T. ASSESSMENT The cortical thickness, loca...更多

Background Cerebral structures in both cortical and subcortical regions change with aging. More specific and comprehensive studies are needed to better elucidate these changes. PURPOSE To investigate the relationships between age and cerebral structures regarding cortical and subcortical changes. Study Type Cross‐cohort research. Population 54 healthy adults aged 21–71 years. Field Strength/Sequence T 1 ‐weighted imaging was performed at 1.5T. ASSESSMENT The cortical thickness, local gyrification index , and the volumes of total gray matter , white matter , white matter hyperintensity , deep gray matter nuclei , ventricles, and hippocampal subfields were obtained using FreeSurfer software. Statistical Tests Regression analysis was performed to determine the relationships between age and cortical thickness, LGI, and volumes of subcortical structures. Uncorrected P values ≤ 0.001 and R 2 > 0.16 were considered significant. Results The cortical thickness and LGI decreased with age throughout almost all brain regions . Except for the volumes of the WM and 4th ventricle , the volumes of the GM, WMH, lateral ventricle, inferior lateral ventricle, and 3rd ventricle showed a nonlinear correlation with aging . For deep gray matter nuclei, the thalamus volume was significantly decreased with aging . Additionally, the hippocampus volume was initially increased and then decreased at age of 50, mainly in the granule cell layer of the dentate gyrus , cornus ammonis 2/3 , CA4, and fissure . The volumes of the putamen, pallidum, accumbens area, amygdala and caudate showed no significance with aging . Data Conclusion The results comprehensively show the relationships between age and cerebral structures in multiple brain regions, and these findings may help identify normal aging and other age‐related neuroradiological disorders.收起

学科

【SCI学科】INSTRUMENTS & INSTRUMENTATION;ENGINEERING, ELECTRICAL & ELECTRONIC;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING 【ESI学科】CLINICAL MEDICINE

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