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作者

Juan Li Chuansong Quan Yun Xie Changwen Ke Yifei Nie Quanjiao Chen Tao Hu Jianjun Chen Gary Wong Qianli Wang Luzhao Feng Hongjie Yu Yingxia Liu Wenjun Liu George F. Gao William J. Liu Weifeng Shi Yuhai Bi

作者单位

Henan Provincial Center for Disease Control and Prevention, Zhengzhou, China National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Yuhai Bi, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early‐warning (CASCIRE), Chinese Academy of Sciences, Beijing, China. Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China and Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early‐warning (CASCIRE), Chinese Academy of Sciences, Beijing, China CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Hubei, China Chinese Center for Disease Control and Prevention, Beijing, China Département de microbiologie‐infectiologie et d'immunologie, Université Laval, Québec, Québec, Canada Weifeng Shi, Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Shandong Universities, Taishan Medical College, Taian, Shandong, China. Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Shandong Universities, Taishan Medical College, Taian, Shandong, China Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China

刊名

Transboundary and Emerging Diseases

关键词

evolution H6 subtype low pathogenic avian influenza molecular characterization reassortment

分类号

636.089

摘要

H6 subtype avian influenza virus was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 were phylogenetically characterized. Our analysis revealed that they could be divided into two clades in the Asian H6 HA lineage, A/wild duck/Shantou/2853/2003 and A/duck/Shantou/339/2000 , in which ST2853‐like strains predominate. These novel strains belonged to the H6N6 , H6N2 , and H6N3 subty...更多

H6 subtype avian influenza virus was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 were phylogenetically characterized. Our analysis revealed that they could be divided into two clades in the Asian H6 HA lineage, A/wild duck/Shantou/2853/2003 and A/duck/Shantou/339/2000 , in which ST2853‐like strains predominate. These novel strains belonged to the H6N6 , H6N2 , and H6N3 subtypes, which could be classified into 36 genotypes including 12 novel genotypes described in this study. In particular, several strains possessed the V190 and S228 mutations in HA , which is critical for human receptor binding and identical to the human‐derived strain A/Taiwan/2/2013. Furthermore, 10.3% of the H6N6 isolates possessed the N6‐∆11b deletion. In summary, we describe phylogenetic and molecular characterizations of H6 AIVs in southern China and highlight the constant prevalence of H6 AIVs in poultry as well as adaptation to mammalian hosts.收起

学科

【SCI学科】VETERINARY SCIENCES;INFECTIOUS DISEASES 【ESI学科】PLANT & ANIMAL SCIENCE

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期刊

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