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作者

Zheng, Xiaowei Zeng, Nimei Wang, Aili Zhu, Zhengbao Zhong, Chongke Xu, Tan Xu, Tian Peng, Yanbo Peng, Hao Li, Qunwei

作者单位

Soochow Univ, Dept Epidemiol, Sch Publ Hlth, Med Coll, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, Med Coll, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China North China Univ Sci & Technol, Affiliated Hosp, Dept Neurol, Tangshan, Hebei, Peoples R China Xuzhou Med Coll, Dept Neurol, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA Kerqin Dist First Peoples Hosp Tongliao City, Dept Neurol, Tongliao City, Inner Mongolia, Peoples R China Taishan Med Coll, Sch Publ Hlth, Dept Epidemiol, Tai An, Shandong, Peoples R China Nantong Univ, Affiliated Hosp, Dept Neurol, Nantong, Jiangsu, Peoples R China

刊名

CURRENT NEUROVASCULAR RESEARCH

年份

2018

卷号

Vol.15 No.3

页码

226-233

ISSN

1567-2026

关键词

C-reactive protein High-density Lipoprotein Cholesterol (HDL-C) stroke ischemic stroke inflammation atherosclerosis

分类号

616.8

摘要

Aims: C-reactive protein is an established marker of inflammation that can impair the protective function of High Density Lipoprotein Cholesterol . The combined effect of C-reactive protein and HDL-C on long-term outcomes in patients with stroke remains uncertain. Methods: A total of 3124 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke were included in this analysis. Participants were divided into four groups according to CRP and HDL-C levels on adm...更多

Aims: C-reactive protein is an established marker of inflammation that can impair the protective function of High Density Lipoprotein Cholesterol . The combined effect of C-reactive protein and HDL-C on long-term outcomes in patients with stroke remains uncertain. Methods: A total of 3124 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke were included in this analysis. Participants were divided into four groups according to CRP and HDL-C levels on admission. The primary outcome was a combination of death and major disability at one year after stroke. Results: Compared to participants with low CRP/ high HDL-C, adjusted odd ratios for primary outcome for those with low CRP/low HDL-C, high CRP /high HDL-C and high CRP /low HDL-C were 1.06 ,1.78 and 2.03, respectively, after multiple adjustments. Adding serum CRP and HDL-C status to a model containing conventional stroke risk factors significantly improve risk reclassification for the combined outcome of death and major disability . Moreover, no interaction was observed between CRP and HDL-C in relation to stroke outcomes . Conclusions: High CRP with low HDL-C levels was associated with death and major disability within one year after ischemic stroke. The findings suggest that the ischemic patients with both high CRP and low HDL-C should be treated with reducing CRP and promoting HDL-C levels.收起

学科

【SCI学科】CLINICAL NEUROLOGY;NEUROSCIENCES 【ESI学科】NEUROSCIENCE & BEHAVIOR

影响因子

2016年:2.298;2015年:2.123;2014年:2.253;2013年:2.735;2012年:2.844

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期刊

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