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作者

Zheng, Xiaowei Zeng, Nimei Wang, Aili Zhu, Zhengbao Zhong, Chongke Xu, Tan Xu, Tian Peng, Yanbo Peng, Hao Li, Qunwei

作者单位

Kerqin Dist First Peoples Hosp Tongliao City, Dept Neurol, Tongliao, Inner Mongolia, Peoples R China North China Univ Sci & Technol, Affiliated Hosp, Dept Neurol, Tangshan, Hebei, Peoples R China Soochow Univ, Med Coll, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, 199 Renai Rd,Ind Pk Dist, Suzhou 215123, Jiangsu, Peoples R China Xuzhou Med Coll, Dept Neurol, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA Soochow Univ, Dept Epidemiol, Sch Publ Hlth, Med Coll, 199 Renai Rd,Ind Pk Dist, Suzhou 215123, Jiangsu, Peoples R China Taishan Med Coll, Sch Publ Hlth, Dept Epidemiol, Tai An, Shandong, Peoples R China Nantong Univ, Affiliated Hosp, Dept Neurol, Nantong, Jiangsu, Peoples R China

刊名

CURRENT NEUROVASCULAR RESEARCH

年份

2018

卷号

Vol.15 No.2

页码

151-157

ISSN

1567-2026

关键词

White blood cell acute ischemic stroke prognostic value CATIS atherosclerosis C-reactive protein

分类号

616.8

摘要

Background and Aims: It is unclear whether white blood cell on admission has a prognosis value on ischemic stroke and whether its function is affected by other inflammation factors. We hypothesized that elevated white blood cell is associated with stroke severity and 3-month mortality after acute ischemic stroke. Methods: A total of 3891 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke were included in this analysis. Participants were divided into fo...更多

Background and Aims: It is unclear whether white blood cell on admission has a prognosis value on ischemic stroke and whether its function is affected by other inflammation factors. We hypothesized that elevated white blood cell is associated with stroke severity and 3-month mortality after acute ischemic stroke. Methods: A total of 3891 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke were included in this analysis. Participants were divided into four groups according to quartiles of white blood cell on admission /L,6.83x10/L,8.50x10/L). The primary outcome was a combination of death and major disability at 3 months. Secondary outcomes were major disability, death, and vascular events, respectively. Results: After adjustment for major conventional risk factors, elevated white blood cell on admission was associated with poor primary and secondary outcomes after acute ischemic stroke. Compared with the lowest quartile, the ORs for the highest quartile were 1.79 and 1.62 for primary outcome in model 1 and model 2. In addition, there was a linear association between white blood cell and primary outcome at 3-months . Conclusion: This analysis indicated that elevated white blood cell on admission is associated with 3-months poor prognosis in ischemic stroke patients independently of other inflammation factors. The results emphasize the need for further research on the application of anti-inflammatory therapy.收起

学科

【SCI学科】CLINICAL NEUROLOGY;NEUROSCIENCES 【ESI学科】NEUROSCIENCE & BEHAVIOR

影响因子

2016年:2.298;2015年:2.123;2014年:2.253;2013年:2.735;2012年:2.844

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期刊

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