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作者

Lu, Chunhui Liang, Ning Hu, Pingping Zhang, Jiandong Zhang, Xuede Liu, Yuanshui Lu, Chunxiao

作者单位

Weifang Med Coll, Dept Oncol, Weifang, Shandong, Peoples R China Taishan Med Univ, Dept Oncol, Tai An, Shandong, Peoples R China Shandong Univ, Dept Oncol, Qianfoshan Hosp, 16766 Jingshi Rd, Jinan 250014, Shandong, Peoples R China Shandong Univ, Dept Radiat Oncol, Qianfoshan Hosp, 16766 Jingshi Rd, Jinan 250014, Shandong, Peoples R China

刊名

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

年份

2018

卷号

Vol.11 No.8

页码

8382-8391

ISSN

1940-5901

关键词

Esophageal squamous cell carcinoma chemoradiotherapy intensity-modulated radiotherapy nedaplatin locally advanced

分类号

616.027

摘要

Here the research was designed to evaluate the safety and efficacy of weekly docetaxel and nedaplatin versus docetaxel and cisplatin when given concurrently with intensity-modulated radiotherapy in locally advanced esophageal carcinoma . From January 2012 to January 2015, 71 patients were enrolled and randomly assigned to the DP group or the DN group. The two groups were both administered with IMRT at a single dose of 2 Gy/F per week for 5 days, 58-60 Gy totally. The DP regimen group was trea...更多

Here the research was designed to evaluate the safety and efficacy of weekly docetaxel and nedaplatin versus docetaxel and cisplatin when given concurrently with intensity-modulated radiotherapy in locally advanced esophageal carcinoma . From January 2012 to January 2015, 71 patients were enrolled and randomly assigned to the DP group or the DN group. The two groups were both administered with IMRT at a single dose of 2 Gy/F per week for 5 days, 58-60 Gy totally. The DP regimen group was treated with 25 mg/m docetaxel on day 1 and 25 mg/m cisplatin on day 2. In the DN regimen group, 25 mg/m docetaxel was administered on day 1 and 25 mg/m nedaplatin on day 2. The results showed that there were no significant differences between the two groups in progression-free survival or 2-year overall survival . The median survival time of living patients was 18 months in the DN group and 16 months in the DP group . The main hematological toxicity was leukocytopenia, which affected 82.1% and 59.4% of the DN and DP groups, respectively . Non-hematological toxicities, such as gastrointestinal toxicity, occurred in 30.8% and 50.6% of the DN and DP groups, respectively . In conclusion, we initially found that IMRT concomitant with a DN regimen was a feasible alternative to DP, performed well, and was a beneficial treatment for EC.收起

学科

【SCI学科】MEDICINE, RESEARCH & EXPERIMENTAL 【ESI学科】BIOLOGY & BIOCHEMISTRY

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