miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7

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作者: Chen, Daiyun Li, Junfu Li, Shunrong Han, Ping Li, Ning Wang, Yi Du, Shouqin

作者单位: Peoples Hosp Zhangqiu, Dept Pathol, Zhangqiu 250200, Shandong, Peoples R China Peoples Hosp Zhangqiu, Dept Crit Care Med, Zhangqiu 250200, Shandong, Peoples R China Taishan Med Univ, Affiliated Hosp, Dept Stomatol, 706 Taishan St, Tai An 271000, Shandong, Peoples R China Peoples Hosp Zhangqiu, Dept Resp Med, Zhangqiu 250200, Shandong, Peoples R China

关键词: luciferase reporter assay miR-184 sex-determining region Y-box 7 tongue squamous cell carcinoma

摘要: The aim of this study was to investigate whether the miR-184 could regulate the proliferation of the tongue squamous cell carcinoma through sex-determining region Y-box 7 gene. miR-184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of miR-184 significantly promoted the proliferation of the TSCC cells in vitro. SOX7 was the direct target of miR-184 and luciferase reporter assay confirmed that miR-184 downregulated the expression of SOX7. MTT as...更多; The aim of this study was to investigate whether the miR-184 could regulate the proliferation of the tongue squamous cell carcinoma through sex-determining region Y-box 7 gene. miR-184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of miR-184 significantly promoted the proliferation of the TSCC cells in vitro. SOX7 was the direct target of miR-184 and luciferase reporter assay confirmed that miR-184 downregulated the expression of SOX7. MTT assay verified that knockdown of SOX7 remarkably promoted the proliferation of TSCC cells in vitro. miR-184 promoted the proliferation of TSCC by targeting SOX7. Taken together, our results provided a new potential therapeutic target for TSCC treatment.收起

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