Department of anesthesiology,Yuhuangding Hospital Affiliated to Medical college of Qingdao university,Yantai,People’s Republic of ChinaDepartment of Oral and Maxillofacial Surgery,The Second Hospital of Shandong University,Jinan,People’s Republic of ChinaDepartment of Otorhinolaryngology,Yantaishan Hospital Affiliated to Medical college of Taishan,Yantai,People’s Republic of ChinaStomatology School of Shandong University,Jinan,People’s Republic of China
This study aims to evaluate the association of E-cadherin expression with the prognosis of oral squamous cell carcinoma . Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the Revman 5.0 guidelines. In the meta-analysis, we utilized either fixed effects or random effects model to pool the HR according to the test of heterogeneity. A total of nine eligible studies included 973 OSCC patients were analyzed. Of the patients, 76.3 % had low...更多
This study aims to evaluate the association of E-cadherin expression with the prognosis of oral squamous cell carcinoma . Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the Revman 5.0 guidelines. In the meta-analysis, we utilized either fixed effects or random effects model to pool the HR according to the test of heterogeneity. A total of nine eligible studies included 973 OSCC patients were analyzed. Of the patients, 76.3 % had low expression of E-cadherin according to the cutoff value defined by the authors. The pooled hazard ratio of low expression of E-cadherin for overall survival was 0.65 ; in Asian population, the HR for overall survival of the patients with reduced expression of E-cadherin was 0.84 , and in non-Asian population, the HR for overall survival of the patients with reduced expression of E-cadherin was 0.54 . Patients with reduced expression of E-cadherin appear to have a poorer OS compared with those with normal or higher expression of E-cadherin.收起
