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作者

Zhang, FY Tang, W Zhang, ZZ Huang, JC Zhang, SX Zhao, XC

作者单位

Department of Orthopaedic Surgery,People’s Hospital of Yucheng City,Yucheng,People’s Republic of China Department of Orthopaedic Surgery,The Third Hospital of Jinan,Jinan,People’s Republic of China First People’s Hospital of Jinan City,Jinan,People’s Republic of China Department of Critical-Care Medicine,Qianfoshan Hospital, Shandong University,Jinan,People’s Republic of China Department of Orthopaedics,Yantaishan Hospital, Medical College of Taishan,Taishan,People’s Republic of China

刊名

Tumour Biology

年份

2014

卷号

Vol.35 No.10

页码

10419-10427

ISSN

1010-4283;1423-0380

关键词

Osteosarcoma High-dose chemotherapy Standard-dose chemotherapy Systematic evaluation

摘要

The objective of this study is to evaluate whether high-dose chemotherapy is more efficacious than standard-dose chemotherapy in the treatment of primary well-differentiated osteosarcoma. The Cochrane systematic evaluation method was adopted. A database search was conducted in MEDLINE, Embase, OVID, the Cochrane Central Register of Controlled Trials database and the Chinese Biomedical Literature CD-ROM Database. The quality of the included studies was jointly evaluated by two reviewers, and homo...更多

The objective of this study is to evaluate whether high-dose chemotherapy is more efficacious than standard-dose chemotherapy in the treatment of primary well-differentiated osteosarcoma. The Cochrane systematic evaluation method was adopted. A database search was conducted in MEDLINE, Embase, OVID, the Cochrane Central Register of Controlled Trials database and the Chinese Biomedical Literature CD-ROM Database. The quality of the included studies was jointly evaluated by two reviewers, and homogeneous studies were included for meta-analysis. A total of five studies were included in this meta-analysis, with 1,415 subjects with primary, nonmetastatic, well-differentiated osteosarcoma in the limbs. No statistically significant differences were found between the high-dose chemotherapy group and the low-dose group in 5-year event-free survival [RR 1.04, 95 %CI ], 5-year overall survival [RR 1.02, 95 %CI ], local recurrence rate [RR 0.90, 95 %CI ], proportion of subjects with good histological response [RR 0.93, 95 %CI ], or limb salvage rate [RR 0.97, 95 %CI ]. A statistically significant difference was observed in the 5-year event-free survival between the subjects with good histological response to preoperative chemotherapy and the subjects with poor histological response [RR 1.55, 95 %CI , P < 0.001]. High-dose chemotherapy did not show superior efficacy to low-dose chemotherapy in the treatment of primary well-differentiated osteosarcoma. Further high-quality randomized controlled trials are needed to provide additional reliable evidence for our observation.收起

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