Department of Anesthesiology,Yuhuangding Hospital Affiliated to Medical College of Qingdao University,Yantai,ChinaDepartment of Clinical Laboratory,QiXia Renmin Hospital Affiliated to Medical College of Binzhou,Qixia,ChinaDepartment of Otorhinolaryngology,Yantaishan Hospital Affiliated to Medical College of Taishan,Yantai,ChinaDepartment of Otorhinolaryngology,Laixi People Hospital,Laixi,China
Data on the association between −1607 1G > 2G polymorphism in the promoter region of matrix metalloproteinase-1 and nasopharyngeal carcinoma are conflicting. The aim of this study was to confirm whether this polymorphism was a causative factor of NPC. We searched PubMed, Embase, and China National Knowledge Infrastructure for studies on the present topic. A total of four publications were included and meta-analysis was performed to assess the association between −1607 1G > 2G polymorph...更多
Data on the association between −1607 1G > 2G polymorphism in the promoter region of matrix metalloproteinase-1 and nasopharyngeal carcinoma are conflicting. The aim of this study was to confirm whether this polymorphism was a causative factor of NPC. We searched PubMed, Embase, and China National Knowledge Infrastructure for studies on the present topic. A total of four publications were included and meta-analysis was performed to assess the association between −1607 1G > 2G polymorphism and NPC risk. Odds ratio with 95 % confidence interval was calculated for 1G1G versus 2G2G, 1G1G + 1G2G versus 2G2G, 1G1G versus 1G2G + 2G2G, 1G versus 2G, and 1G2G versus 2G2G contrast models. Meta-analysis results showed significantly reduced risk of NPC associated with the 1G1G versus 2G2G, 1G versus 2G and 1G2G versus 2G2G contrast models . When we continued to perform subgroup analysis by ethnicity, the significant association persisted in Asian population and was most pronounced under the 1G2G versus 2G2G model . These data suggested that MMP1 −1607 1G > 2G polymorphism was associated with reduced risk of NPC, particularly in the population of Asian descent.收起
