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作者

Dong, Jian Zhao, Yanli Wang, Kaiqi Chen, Hongyu Liu, Li Sun, Baoliang Yang, Mingfeng Sun, Liping Wang, Yi Yu, Xuegang

作者单位

Taishan Med Univ, Sch Chem & Pharmaceut Engn, Tai An 271016, Shandong, Peoples R China Taishan Med Univ, Dept Ophthalmol, Affiliated Hosp, Tai An 271016, Shandong, Peoples R China Taishan Med Univ, Affiliated Hosp, Dept Neurol, Tai An 271016, Shandong, Peoples R China Qingdao Univ Sci & Technol, Coll Mat Sci & Engn, Qingdao 266042, Shandong, Peoples R China Taishan Med Univ, Inst Optometry, Affiliated Hosp, Tai An 271016, Shandong, Peoples R China Univ Shandong, Key Lab Cerebral Microcirculat, Tai An 271016, Shandong, Peoples R China

刊名

CHEMISTRYSELECT

年份

2018

卷号

Vol.3 No.44

页码

12696-12703

ISSN

2365-6549

关键词

drug delivery fluorescence imaging graphitic carbon nitride pH-responsive quantum dots

摘要

A simple approach is developed to produce fluorescent graphitic carbon nitride quantum dots by refluxing bulk graphitic carbon nitride in HNO3 followed by a direct hydrothermal treatment. Owing to their small size, intrinsic optical properties, low toxicity, and useful non-covalent interactions with the antitumor drug doxorubicin , g-CNQDs are investigated as fluorescent nanocarriers for DOX without any pre-modification. The inherent fluorescence of g-CNQDs and DOX provides the drug delivery s...更多

A simple approach is developed to produce fluorescent graphitic carbon nitride quantum dots by refluxing bulk graphitic carbon nitride in HNO3 followed by a direct hydrothermal treatment. Owing to their small size, intrinsic optical properties, low toxicity, and useful non-covalent interactions with the antitumor drug doxorubicin , g-CNQDs are investigated as fluorescent nanocarriers for DOX without any pre-modification. The inherent fluorescence of g-CNQDs and DOX provides the drug delivery system with dual-color imaging for revealing the intracellular localization of g-CNQDs and DOX release. The release profiles of DOX from g-CNQDs-DOX reveal a strong dependence on the environmental pH value, which is beneficial for mollifying side effects following chemotherapy. Cellular uptake of g-CNQDs-DOX indicates that not only DOX but also some g-CNQDs penetrate cell nuclei after 16 h of incubation, which leads g-CNQDs-DOX to be more toxic than DOX. The results demonstrate the feasibility of using g-CNQDs as a traceable and pH-responsive drug delivery system due to their unique structural properties.收起

学科

【SCI学科】CHEMISTRY, MULTIDISCIPLINARY

影响因子

2017年:1.505;2016年:-999.999

文献类型

期刊

浏览量

22