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作者

Yuanfu Lu Xue-Mei Zhao Zhaoyong Hu Li Wang Feng Li

作者单位

Department of Molecular and Cellular Biology, Advance Technology Core,Baylor College of Medicine,Houston,USA Center for Drug Discovery,Baylor College of Medicine,Houston,USA Nephrology Division, Department of Medicine,Baylor College of Medicine,Houston,USA Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi,China Department of Internal Medicine, Section of Digestive Diseases,Yale University,New Haven,USA Veterans Affairs Connecticut Healthcare System,West Haven,USA College of Pharmacy,Taishan Medical University,Tai’an,China Department of Physiology and Neurobiology, and The Institute for Systems Genomics,University of Connecticut,Storrs,USA

刊名

Current Pharmacology Reports

年份

2019

卷号

Vol.5 No.1

页码

56-67

ISSN

2198-641X

关键词

Metabolomics Drug metabolism Reactive metabolite Liver toxicity Biomarkers

摘要

Purpose of Review Metabolomics is the systematic and comparative study of the levels of small-molecule metabolites in samples under various conditions. In biological system, metabolites play a critical role in a diversity of cellular functions. Metabolomics has been widely employed in toxicology and other fields. The purpose of this review is to summarize recent literatures on the application of LC–MS-based metabolomics in drug bioactivation and drug-induced liver injury and to discuss their c...更多

Purpose of Review Metabolomics is the systematic and comparative study of the levels of small-molecule metabolites in samples under various conditions. In biological system, metabolites play a critical role in a diversity of cellular functions. Metabolomics has been widely employed in toxicology and other fields. The purpose of this review is to summarize recent literatures on the application of LC–MS-based metabolomics in drug bioactivation and drug-induced liver injury and to discuss their challenges in the field of toxicology. Recent Findings The emerging metabolomics could provide us a comprehensive view of novel biochemical sequelae in the cells, tissues, and organisms following toxicant administration. This article reviews LC–MS-based metabolomics in identification of biomarkers of drug toxicity and elucidating mechanisms of toxicity reported in recent years. This review also discusses the application of metabolomics combined with genomics or proteomics in the research field of DILI. Summary LC–MS-based metabolomics has a great potential in drug metabolism, identification of biomarkers of cause and/or effect, and revealing the novel mechanisms of drug toxicity. In the future, metabolomics integrating with other omics can serve as an effective tool for investigating the mechanisms of drug toxicity.收起

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