Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, 200233, Shanghai, People's Republic of China Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200135, Shanghai, China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, 200135, Shanghai, China Department of Orthopedics, Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine & Health Sciences, 201306, Shanghai, China Taishan Medical University, 271016, Taian, China Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, and School of Pharmacy, Shanghai Jiao Tong University, 200240, Shanghai, China
刊名
BMC Infectious Diseases (BMC INFECT DIS)
年份
2018
卷号
Vol.18 No.1
ISSN
1471-2334
摘要
Background: China had the third highest burden of tuberculosis population in the world. Bone and joint tuberculosis was a major part and its characteristics were rarely discussed before. This study was designed to review the characteristics and management of bone and joint tuberculosis among native and migrant population in Shanghai, China during 2011-2015.Methods: A retrospective analysis of the patient clinical records on their demographic information, clinical features and treatment was condu...更多
Background: China had the third highest burden of tuberculosis population in the world. Bone and joint tuberculosis was a major part and its characteristics were rarely discussed before. This study was designed to review the characteristics and management of bone and joint tuberculosis among native and migrant population in Shanghai, China during 2011-2015.Methods: A retrospective analysis of the patient clinical records on their demographic information, clinical features and treatment was conducted from three tertiary referral hospitals. Analysis of continuous variables included calculation of the median value with interquartile range. Categorical variables were displayed as percentages and compared using the Fisher's exact test and chi-square test. All continuous variables were compared using Student's unpaired t-test and Mann Whitney U test.Results: One hundred fifteen patients with bone and joint tuberculosis were involved in this study. Native people were generally older and had more comorbidities like hypertension , diabetes mellitus , and cancer than migrants. Migrant patients generally experienced a longer period of uncomfortable feelings before going to doctor than native people . Spine was a major infection site in comparison with other peripheral joints. Radiological evaluation displayed increased osteolytic reaction in migrant patients compared with native people . The mean time for anti-tuberculosis treatment was significantly longer in native Shanghai patients . The curative ratio displayed a significant difference between native and migrant patients .Conclusion: Bone and joint tuberculosis exhibited a poorer outcome in migrant people, who also had longer period of manifestation, more severe osteolytic reaction from CT scan and higher recurrent rate than native people. The surgical treatment in addition to anti-tuberculosis drug therapy had great implications for bone and joint tuberculosis recovery.收起
