Factors affecting establishment of rodent alcohol drinking models and recent advances

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作者单位: Institute of Pharmacology, Universities of Shandong, Taishan Medical College, Tai'an, China Department of Medical Psychology, School of Basic Medical Sciences, Universities of Shandong, Taishan Medical College, Tai'an, China Key Lab of Cerebral Microcirculation, Universities of Shandong, Taishan Medical College, Tai'an, China Department of Ophthalmology, Tai'an Central Hospital, Tai'an, China Department of Behavioral Medicine and Psychiatry and Physiology and Pharmacology, Blanchette Rockefeller Neurosciences Institute, West Virginia University, Health Sciences Center, Morgantown, WV, United States

摘要: Alcohol use disorder is one of the main factors that threaten human health and life. WHO data show that about 3.3 million people die each year worldwide due to AUD. AUD has become a global public health concern, but its neurobiological and behavioral mechanisms remain unclear. Therefore, it is particularly urgent to develop valid and reliable animal models to investigate the underlying mechanisms of AUD. This review summarizes the animal species and modeling methods of AUD in order to explore t...更多; Alcohol use disorder is one of the main factors that threaten human health and life. WHO data show that about 3.3 million people die each year worldwide due to AUD. AUD has become a global public health concern, but its neurobiological and behavioral mechanisms remain unclear. Therefore, it is particularly urgent to develop valid and reliable animal models to investigate the underlying mechanisms of AUD. This review summarizes the animal species and modeling methods of AUD in order to explore the potential influence on the deviation of modeling in alcohol intake and provide helpful inputs to behavioral research of AUD.收起

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