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作者

Xu H. Zhu J.-Z. Sun X.-D. Zhao M. Li C.-F.

作者单位

Radiological College of Taishan Medical College, Taian 271016, China Department of Radiology, The Affiliated Hospital of Taishan Medical College, Taian 271000, China Taian Testing Institute of Metrology, Taian 271000, China Department of Radiology, Qilu Hospital, Shandong University, Ji'nan 250012, China

刊名

Chinese Journal of Medical Imaging Technology

年份

2011

卷号

Vol.27 No.10

页码

1963-1966

ISSN

1003-3289

关键词

Alcohol Magnetic resonance imaging Nonhuman primate Smell

摘要

Objective: To explore the fMRI changes of brain in macaca fascicularis with alcohol scent stimulation. Methods: Six healthy macaca fascicularis were selected and anesthetized. The block design was 'rest-stimulation-rest'. fMRI under alcohol scent stimulation and resting state were performed, respectively. The animals inhaled air mixed with 95% alcohol in the stimulation period, while inhaled pure air in rest period. BOLD-fMRI sequences and 128 phases scanning were performed, 16 slices axial imag...更多

Objective: To explore the fMRI changes of brain in macaca fascicularis with alcohol scent stimulation. Methods: Six healthy macaca fascicularis were selected and anesthetized. The block design was 'rest-stimulation-rest'. fMRI under alcohol scent stimulation and resting state were performed, respectively. The animals inhaled air mixed with 95% alcohol in the stimulation period, while inhaled pure air in rest period. BOLD-fMRI sequences and 128 phases scanning were performed, 16 slices axial images of the entire brain and total 2048 images were obtained. Data were analyzed using SPM2. The outcomes were superposed on the template of macaca fascicularis at last. Random effect mode group analysis was applied in estimating and calculating with t-test. Results: When alcohol scent stimulation was given, increased or decreased BOLD signals were observed in frontal lobe, temporal lobe, paracentral lobules, cingulate gyri, and lenticular nucleus, and anterior central gyrus, respectively. Conclusion: Uncus gyri hippocampi and orbitofrontal are the most advanced center of olfaction. The central reaction induced by scent stimulation had an affinity with paracentral lobule, cingulate gyrus and lenticular nucleus.收起

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