Objective: To explore the effects of serum bilirubin on endothelium-dependent dilation of artery. Methods: One hundred patients with cardiovascular diseases were included and divided into 3 groups: coronary heart disease group , hypertension group , coronary heart disease combined with hypertension group , and 37 normal volunteers were enrolled as control group. Flow-mediated dilation of humeral artery was measured by high resolution ultrasonography with GE VIVID 7 system. Serum bilirubin levels...更多
Objective: To explore the effects of serum bilirubin on endothelium-dependent dilation of artery. Methods: One hundred patients with cardiovascular diseases were included and divided into 3 groups: coronary heart disease group , hypertension group , coronary heart disease combined with hypertension group , and 37 normal volunteers were enrolled as control group. Flow-mediated dilation of humeral artery was measured by high resolution ultrasonography with GE VIVID 7 system. Serum bilirubin levels were measured by automatic chemical analyzer. Results: In cardiovascular diseases group, flow-mediated dilation and the changes of blood flow during the reactive hyperaemia stage were significantly lower than those in control group, while total and indirect serum bilirubin correlated positively with FMD and the changes of blood flow during the reactive hyperaemia stage. Multi-variable stepwise regression indicated that the correlation was independent of other conventional risk factors such as age, smoking, systolic and diastolic blood pressure, pulse pressure, and so on. Conclusion: The FMD and the changes of blood flow during the reactive hyperaemia stage correlate negatively and significantly with serum total and indirect bilirubin. The level of total serum bilirubin is an independent risk factor of the endothelium-dependent dilation function.收起
