Department of Neurology, Hospital of Taishan Medical College, Taian 271000 Shandong Province, China Department of Neurology, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022 Hubei Province, China
刊名
Chinese Journal of Clinical Rehabilitation
年份
2005
卷号
Vol.9 No.16
页码
18-19
ISSN
1671-5926
摘要
Aim: To investigate the relation of post-stoke depression with the stoke site and severity of neurologic impairment, and the interventional effect of antidepressant treatment. Methods: Totally 268 patients with depression of different severity at years of age, were screened out from 732 stroke patients at acute phase, who were hospitalized in the Department of Neurology, Affiliated Hospital of Taishan Medical College between September 2001 and September 2004, and there were 198 cases of basal ga...更多
Aim: To investigate the relation of post-stoke depression with the stoke site and severity of neurologic impairment, and the interventional effect of antidepressant treatment. Methods: Totally 268 patients with depression of different severity at years of age, were screened out from 732 stroke patients at acute phase, who were hospitalized in the Department of Neurology, Affiliated Hospital of Taishan Medical College between September 2001 and September 2004, and there were 198 cases of basal ganglion damage and 36 cases of cortex damage. The 268 patients were randomly divided into treatment group and control group, all the patients received routine treatment, besides those in the treatment group were treated with doxepin hydrochloride tablets. The depressive severity and degree of neurologic impairment of the patients were evaluated with center for epidemiological studies-depression scale and assessment standard of cerebral stroke nerve function defect respectively before and after treatment, so as to investigate the association between the depressive severity and damaged site. Results: According to intention-to-treat analysis, all the 268 patients with post-stroke depression were involved in the analysis of results. 1 Among the 98 cases with mild depression, whose total score of sel-rating depression scale was 20 to 25, 85 cases had basal ganglion and cortex damages; Among the 153 cases with moderate to severe depression, whose total score of sell-rating depression scale was more than 25, 139 cases had basal ganglion and cortex damages; Basal ganglion and cortex damages occurred more in mild depressive patients than in moderate to severe depressive patients; That in the treatment group after treatment was obviously lower than that before treatment and that in the control group after treatment; 3 The score of center for epidemiological studies-depression scale in the treatment group after treatment was markedly lower than that before treatment and that in the control group after treatment; 4 The score of center for epidemiological studies-depression scale had obvious positive correlation with the score of neurologic impairment . Conclusion: Post-stroke depression is correlated with the damaged site, and the depressive severity affects the recovery of neurological function, which can be promoted by the antidepressant treatment.收起
