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作者

Zhu Y.-Y. Jiang L.-M. Zhang F. Chen W. Chen M.-H. Wang X.-D. Gao Y.-S.

作者单位

College of Pharmacy, Taishan Medical University, Taian 271000 Shandong Province, China Taishan Sanatorium of Shandong Province, Taian 271000 Shandong Province, China

刊名

Chinese Journal of Clinical Rehabilitation

年份

2005

卷号

Vol.9 No.24

页码

168-169

ISSN

1671-5926

摘要

Aim: To observe the effect of aqueous extract from Herba Eclipta on the survival time and oxygen consumption in hypoxic mice, and evaluate the hypoxia tolerance of Herba Eclipta. Methods: The experiment was finished in the Comprehensive Laboratory of Pharmacology, College of Pharmacy, Taishan Medical University from August to December 2004. Thirty-three mice were randomly divided into three groups and respectively administered with normal saline 30 mL/kg and different dosages of aqueous extract ...更多

Aim: To observe the effect of aqueous extract from Herba Eclipta on the survival time and oxygen consumption in hypoxic mice, and evaluate the hypoxia tolerance of Herba Eclipta. Methods: The experiment was finished in the Comprehensive Laboratory of Pharmacology, College of Pharmacy, Taishan Medical University from August to December 2004. Thirty-three mice were randomly divided into three groups and respectively administered with normal saline 30 mL/kg and different dosages of aqueous extract from Herba Eclipta at the dose of 15 g/kg and 30 g/kg. Changes of the survival time and oxygen consumption in mice were mesured. Results: All the 33 mice were involved in the result analysis. Compared with the group of the normal saline , aqueous extract from Herba Eclipta at the dose of 15 and 30 g/kg made the cumulative oxygen consumption respectively reduced by 19.05% and 66.67% in 0-5 minutes and 19.70% and 32.03% in 5-10 minutes. The survival rate of mice with hypoxia in 50 minutes were 34%, 45% and 100%, in 60 minutes 18%, 18% and 60 %, and in 70 minutes 0, 0 and 3% when receiving normal saline and aqueous extract from Herba Eclipta of 15 and 30 g/kg. Conclusion: The aqueous extract from Herba Eclipta can reduce the cumulative oxygen consumption in different time and enhance the hypoxia tolerance in mice,especially the large-dose extract.收起

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