Department of Pharmacology, Taishan Medical College, Taian 271000 Shandong Province, China Dept. of Renal Internal Medicine, 88 Hospital of Chinese PLA, Taian 271000 Shandong Province, China Department of Pharmacology, Norman Bethune Medical College, Jilin University, Changchun 130021 Jilin Province, China
刊名
Chinese Journal of Clinical Rehabilitation
年份
2004
卷号
Vol.8 No.13
页码
2454-2455
ISSN
1671-5926
摘要
Aim: To establish rat models of non-hereditary Alzheimer's disease by damaging bilateral nucleus basalis of Meynert with quinolinic acid. Methods: Bilateral NBM of elderly rats were damaged with quinolinic acid . One-off step-down passive avoidance training and water-maze spatial localization task were conducted to observe the ability of learning and memory in the rats The effects of 1, 2, 3, 4-tetrahydroacridine on learning and memory of the rat with damaged NBM were also observed. Results: C...更多
Aim: To establish rat models of non-hereditary Alzheimer's disease by damaging bilateral nucleus basalis of Meynert with quinolinic acid. Methods: Bilateral NBM of elderly rats were damaged with quinolinic acid . One-off step-down passive avoidance training and water-maze spatial localization task were conducted to observe the ability of learning and memory in the rats The effects of 1, 2, 3, 4-tetrahydroacridine on learning and memory of the rat with damaged NBM were also observed. Results: Compared with the sham-lesion group, the number of errors in the step-down trial 13 days after NBM damage was increased significantly . So was the training times to reach the criterion in the water-maze task 16 days after damage . Compared with the quinolinic acid group, the number of errors in the step-down trial after the rats were intraperitoneally injected with THA 10 mg/ for 13 days was decreased obviously . So was the training times to reach the criterion in the water maze task 16 days after intraperitoneal injection of THA. Conclusion: Rat models of non-hereditary AD can he made by damaging bilateral NBM with quinolinic acid.收起
