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作者

Liu, W. Gao, C. Dai, H. Zheng, Y. Dong, Z. Gao, Y. Liu, F. Zhang, Z. Liu, Z. Liu, B. Liu, Q. Shi, J.

作者单位

a Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China Shunyi Branch, Beijing Hospital of Traditional Chinese Medicine, Beijing, China Taishan Medical University, Shandong, China g Departments of Medicine, VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States f Key Laboratory of Chinese Internal Medicine of Ministry of Education, Beijing, China Capital Medical University, Beijing, China Beijing University of Chinese Medicine, Beijing, China

刊名

Frontiers in immunology

年份

2019

卷号

Vol.10

ISSN

1664-3224;1664-3224

关键词

immunological pathogenesis kidney lung membranous nephropathy PLA2R1 PM2.5

摘要

Membranous nephropathy is the major cause of nephrotic syndrome with special pathological features, caused by the formation of immune complexes in the space between podocytes and the glomerular basement membrane. In idiopathic membranous nephropathy the immune complexes are formed by circulating antibodies binding mainly to one of two naturally-expressed podocyte antigens: the M-type receptor for secretory phospholipase A2 and the Thrombospondin type-1 domain-containing 7A . Formation of anti...更多

Membranous nephropathy is the major cause of nephrotic syndrome with special pathological features, caused by the formation of immune complexes in the space between podocytes and the glomerular basement membrane. In idiopathic membranous nephropathy the immune complexes are formed by circulating antibodies binding mainly to one of two naturally-expressed podocyte antigens: the M-type receptor for secretory phospholipase A2 and the Thrombospondin type-1 domain-containing 7A . Formation of antibodies against PLA2R1 is much more common, accounting for 70-80% of IMN. However, the mechanism of anti-podocyte antibody production in IMN is still unclear. In this review, we emphasize that the exposure of PLA2R1 is critical for triggering the pathogenesis of PLA2R1-associated MN, and propose the potential association between inflammation, pollution and PLA2R1. Our review aims to clarify the current research of these precipitating factors in a way that may suggest future directions for discovering the pathogenesis of MN, leading to additional therapeutic targets and strategies for the prevention and early treatment of MN.收起

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