Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injur y in rat hippocampus

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作者: Zhang Wangxin Zhang Qiuling Deng Wen Li Yalu Xing Guoqing Shi Xianjun Du Yifeng

作者单位: Department of Neurology，Shandong Provincial Hospital，Jinan，Shandong China；Department of Neurology，Shandong Provincial Hospital，Jinan，Shandong China；Department of Medical Psychology，Taishan Medical，Taian，Shandong China；Department of Medical Psychology，Taishan Medical University，Shandong China；Department of Medical Psychology，Taishan Medical University，Shandong China；Department of Medical Psychology，Taishan Medical，Taian，Shandong China；Department of Medical Psychology，Taishan Medical，Taian，Shandong China.

关键词: nerve regeneration cerebral ischemia/reperfusion ganoderma lucidum anti-oxidative anti-inflammatory superoxide dismutase malondialdehyde interleukin-8 tumor necrosis factor-alpha apoptosis hippocampus neural regeneration

摘要: Ganoderma lucidum is a traditional Chinese medicine, which has been shown to have both an-ti-oxidative and anti-inlfammatory effects, and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex. This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rats. Our results showed that pretreatment with ganoder-ma lucidum for 3 and 7 days reduced neuronal loss in the hippoc...更多; Ganoderma lucidum is a traditional Chinese medicine, which has been shown to have both an-ti-oxidative and anti-inlfammatory effects, and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex. This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rats. Our results showed that pretreatment with ganoder-ma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus, diminished the content of malondialdehyde in the hippocampus and serum, decreased the levels of tumor necrosis fac-tor-alphaand interleukin-8 in the hippocampus, and increased the activity of superoxide dismutase in the hippocampus and serum. hTese results suggest that pretreatment with ganoderma lucidum was protective against cerebral ischemia/reperfusion injury through its anti-oxidative and an-ti-inlfammatory actions.收起

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