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作者

Xia, C. Wang, K. Xu, J. Shen, C. Sun, D. Li, H. Wang, G. Zhang, P.

作者单位

College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, China a Pharmacy College, Taishan Medical University, Tai'an, 271016, China College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, China

刊名

Organic and Biomolecular Chemistry

年份

2017

卷号

Vol.15 No.3

页码

531-535

ISSN

1477-0520

摘要

The remote C-O coupling of quinoline amides at the C5 position has been established using cheap and readily available copper catalyst under mild conditions. The positionally selective esterification protocol afforded C-O coupling products in moderate to excellent yields. Most importantly, this method may provide a potential alternative to the existing ways to build functionalized 5-hydroxyquinoline derivatives, which are utilized as pivotal intermediates in the synthesis of drug candidates.

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