Selective remote esterification of 8-aminoquinoline amides via copper-catalyzed C-O cross-coupling reaction

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作者单位: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, China a Pharmacy College, Taishan Medical University, Tai'an, 271016, China College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, China

摘要: The remote C-O coupling of quinoline amides at the C5 position has been established using cheap and readily available copper catalyst under mild conditions. The positionally selective esterification protocol afforded C-O coupling products in moderate to excellent yields. Most importantly, this method may provide a potential alternative to the existing ways to build functionalized 5-hydroxyquinoline derivatives, which are utilized as pivotal intermediates in the synthesis of drug candidates.

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