获取途径

作者

Ji, Y.-B. Bo, C.-L. Xue, X.-J. Weng, E.-M. Gao, G.-C. Dai, B.-B. Ding, K.-W. Xu, C.-P.

作者单位

Yanggu No. School of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China School of Nursing, Taishan Medical College, Tai'an, Shandong Province, China School of Nursing, Cheeloo Health Science Center, Shandong University, Jinan, Shandong Province, China a Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, China People's Hospital, Liaocheng, Shandong Province, China

刊名

Journal of Pain and Symptom Management

年份

2017

卷号

Vol.54 No.6

页码

843-852

ISSN

0885-3924

关键词

cancer cluster analysis cytokine Symptom cluster

摘要

Context Pain, fatigue, depression, and sleep disturbance are common in patients with cancer and usually co-occur as a symptom cluster. However, the mechanism underlying this symptom cluster is unclear. Objectives This study aimed to identify subgroups of cluster symptoms, compare demographic and clinical characteristics between subgroups, and examine the associations between inflammatory cytokines and cluster symptoms. Methods Participants were 170 Chinese inpatients with cancer from two tertiar...更多

Context Pain, fatigue, depression, and sleep disturbance are common in patients with cancer and usually co-occur as a symptom cluster. However, the mechanism underlying this symptom cluster is unclear. Objectives This study aimed to identify subgroups of cluster symptoms, compare demographic and clinical characteristics between subgroups, and examine the associations between inflammatory cytokines and cluster symptoms. Methods Participants were 170 Chinese inpatients with cancer from two tertiary hospitals. Inflammatory markers including interleukin-6 , interleukin-1 receptor antagonist, and tumor necrosis factor alpha were measured. Intergroup differences and associations of inflammatory cytokines with the cluster symptoms were examined with one-way analyses of variance and logistic regression. Results Based on cluster analysis, participants were categorized into Subgroup 1 , Subgroup 2 , or Subgroup 3 . The three subgroups differed significantly in Eastern Cooperative Oncology Group performance status, sex, residence, current treatment, education, economic status, and inflammatory cytokines levels . Compared with Subgroup 1, Subgroup 3 had a significantly poorer ECOG physical performance status and higher IL-6 levels, were more often treated with combined chemoradiotherapy, and were more likely to be rural residents. IL-6 and ECOG physical performance status were significantly associated with 1.246-fold and 31.831-fold increased risk of Subgroup 3. Conclusion Our findings suggest that IL-6 levels are associated with cluster symptoms in cancer patients. Clinicians should identify patients at risk for more severe symptoms and formulate novel target interventions to improve symptom management.收起

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期刊

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