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作者

Liu, S. Xie, F. Xiang, X. Dong, S. Qu, K. Lin, T.

作者单位

a Department of The Second General Surgery, Shaanxi Provincial People's Hospital, Xi'an, 710068, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China Department of Pediatrics, Liaocheng People's Hospital, Taishan Medical College, Liaocheng, 252000, China Department of Surgical Intensive Care Units, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China

刊名

Oncotarget

年份

2017

卷号

Vol.8 No.57

页码

97554-97564

ISSN

1949-2553

关键词

Hepatoblastoma LncRNA Malignant phenotype MiRNA MRNA

摘要

Hepatoblastoma is one of the most common hepatic malignancies in the pediatric population. HB are composed of a variety of tumors, which derived from different origins and had varying clinical outcomes. However, the unclear underlying mechanisms of HB limited exploring novel biomarkers and effective therapeutic targets. We searched microarray datasets on Gene Expression Omnibus database and selected GSE75271 and GSE75283 datasets for comprehensive analysis. Weighted gene correlation network an...更多

Hepatoblastoma is one of the most common hepatic malignancies in the pediatric population. HB are composed of a variety of tumors, which derived from different origins and had varying clinical outcomes. However, the unclear underlying mechanisms of HB limited exploring novel biomarkers and effective therapeutic targets. We searched microarray datasets on Gene Expression Omnibus database and selected GSE75271 and GSE75283 datasets for comprehensive analysis. Weighted gene correlation network analysis was employed to identify genes which were associated with tumor malignant phenotypes, including HB subtypes, Cairo classification and tumor stage. Coexpression analysis of identified genes was also performed and lncRNA-miRNA-mRNA network was finally conducted. Our results showed that a total of 22 lncRNAs, 13 miRNAs and 66 mRNAs were identified to be associated with tumor malignant phenotypes. Mechanistically, these molecules might promote the malignant phenotypes via regulating metabolic pathways. Among of them, 6 miRNAs , 8 lncRNAs , and 6 mRNAs were selected to conduct a lncRNAmiRNA- mRNA network. Taken together, our findings provide evidence for exploring molecular mechanisms of HB. Those identified malignant phenotype-associated molecules might be potential biomarkers and anti-cancer therapeutic targets in future.收起

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期刊

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