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作者

Xu, H.-M. Tan, L. Wan, Y. Tan, M.-S. Zhang, W. Zheng, Z.-J. Kong, L.-L. Wang, Z.-X. Jiang, T. Yu, J.-T.

作者单位

Department of Geriatric, Qingdao Mental Health Center, Qingdao, 266034, China Donghai Middle Road, Qingdao, Shandong Province 266071, China a Department of Neurology, Qingdao Municipal Hospital, Taishan Medical University, Qingdao, China Department of Emergency, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, 266000, China g Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, United States f Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China

刊名

Molecular Neurobiology

年份

2017

卷号

Vol.54 No.2

页码

1187-1195

ISSN

0893-7648

关键词

Alzheimer’s disease Meta-analysis Polymorphism Progranulin rs5848

摘要

Progranulin plays an important role in Alzheimer’s disease through participating in altering neurite outgrowth and neuronal survival. Previous studies identified that rs5848 in the 3′-untranslated region of the PGRN gene is strongly associated with AD in Caucasians. In order to assess the involvement of the GRN polymorphism in the risk of late-onset AD , we analyzed the genotype and allele distributions of rs5848 in 2350 Han Chinese subjects . The minor T allele of rs5848 was significantly a...更多

Progranulin plays an important role in Alzheimer’s disease through participating in altering neurite outgrowth and neuronal survival. Previous studies identified that rs5848 in the 3′-untranslated region of the PGRN gene is strongly associated with AD in Caucasians. In order to assess the involvement of the GRN polymorphism in the risk of late-onset AD , we analyzed the genotype and allele distributions of rs5848 in 2350 Han Chinese subjects . The minor T allele of rs5848 was significantly associated with an increased risk of LOAD = 1.197, 95 % confidence interval = 1.057–1.355). Moreover, the association was further validated in the multivariate logistic regression analysis . Interestingly, we observed that the interaction between apolipoprotein E and rs5848 significantly altered the risk for AD. The rs5848 polymorphism was only significantly associated with LOAD in APOE ε4 allele carriers. Then we included five studies and conducted a meta-analysis which consisted of 3236 cases and 3405 controls. The result of the meta-analysis supported T allele of rs5848 within GRN as a risk factor for AD. In conclusion, our results demonstrated that rs5848 polymorphism within GRN was associated with LOAD.收起

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