Department of Physiology, Taishan Medical College, Taian 271000, ChinaBasic Medical College, Tianjin Medical University, Tianjin 300070, ChinaTianjin Medical College, Tianjin 300222, Chinaa Department of Physiology, Tianjin Medical University, Tianjin 300070, China
Objective: To study and evaluate a new internal capsule hemorrhage animal model. Methods: We established an internal capsule hemorrhage animal model using Horseley-Clarke technique. Internal capsule was orientated referring to Sawyer rabbit brain stereotaxic atlas. The model was duplicated by injecting 0.5 ml autologous arterial blood into hind limb of internal capsule. We used HE stain to observe the changes of brain tissues. Then somatosensory evoked potential, and intracranial pressure were m...更多
Objective: To study and evaluate a new internal capsule hemorrhage animal model. Methods: We established an internal capsule hemorrhage animal model using Horseley-Clarke technique. Internal capsule was orientated referring to Sawyer rabbit brain stereotaxic atlas. The model was duplicated by injecting 0.5 ml autologous arterial blood into hind limb of internal capsule. We used HE stain to observe the changes of brain tissues. Then somatosensory evoked potential, and intracranial pressure were measured. Results: Obvious hematoma was detected in brain tissues under light microscopes. The latency of N1 and P1 in somatosensory evoked potential prolonged and the peak-to-peak value of N2-P1 decreased. Meantime intracranial pressure increased. Conclusion: We established an internal capsule hemorrhage animal model successfully. Histopathologic changes of the brain tissues and abnormal somatosensory evoked potential were found. We observed an increase in intracrnial pressure. These can provide the reference for the study of intracerebral hemorrhage.收起
