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作者

Jin, X. Zhang, Z. Jing, W. Zhao, J.

作者单位

Department of Physiology, Taishan Medical College, Taian 271000, China Basic Medical College, Tianjin Medical University, Tianjin 300070, China Tianjin Medical College, Tianjin 300222, China a Department of Physiology, Tianjin Medical University, Tianjin 300070, China

刊名

Journal of Brain Science

年份

2013

卷号

Vol.41

页码

5-16

ISSN

1341-5301

关键词

Internal capsule hemorrhage Intracranial pressure Somatosensory evoked potential

摘要

Objective: To study and evaluate a new internal capsule hemorrhage animal model. Methods: We established an internal capsule hemorrhage animal model using Horseley-Clarke technique. Internal capsule was orientated referring to Sawyer rabbit brain stereotaxic atlas. The model was duplicated by injecting 0.5 ml autologous arterial blood into hind limb of internal capsule. We used HE stain to observe the changes of brain tissues. Then somatosensory evoked potential, and intracranial pressure were m...更多

Objective: To study and evaluate a new internal capsule hemorrhage animal model. Methods: We established an internal capsule hemorrhage animal model using Horseley-Clarke technique. Internal capsule was orientated referring to Sawyer rabbit brain stereotaxic atlas. The model was duplicated by injecting 0.5 ml autologous arterial blood into hind limb of internal capsule. We used HE stain to observe the changes of brain tissues. Then somatosensory evoked potential, and intracranial pressure were measured. Results: Obvious hematoma was detected in brain tissues under light microscopes. The latency of N1 and P1 in somatosensory evoked potential prolonged and the peak-to-peak value of N2-P1 decreased. Meantime intracranial pressure increased. Conclusion: We established an internal capsule hemorrhage animal model successfully. Histopathologic changes of the brain tissues and abnormal somatosensory evoked potential were found. We observed an increase in intracrnial pressure. These can provide the reference for the study of intracerebral hemorrhage.收起

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