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作者

Zhu, Y. Liu, A. Zhang, X. Qi, L. Zhang, L. Xue, J. Liu, Y. Yang, P.

作者单位

Department of Pathology, Tianjin Huan Hu Hospital, Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration, Tianjin, 300060, China a Department of Clinical Laboratory, Tianjin Huan Hu Hospital, Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration, Tianjin, 300060, China School of Public Health, Taishan Medical University, Tai An, 271016, China Department of Traditional Chinese Medicine, General Hospital of Tianjin Medical University, Tianjin, 300052, China Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, The Key Laboratory of Tianjin Cancer Prevention and Treatment, Tianjin, 300070, China

刊名

Tumor Biology

年份

2015

卷号

Vol.36 No.5

页码

3499-3509

ISSN

1010-4283

关键词

Alkylglycerone phosphate synthase Benzyl isothiocyanate Computer-aided design Glioma

摘要

Benzyl isothiocyanate has been shown to have inhibitory potential for human glioma U87MG cells; however, the effect and mechanism were not fully clear. In the present study, we found that BITC could inhibit U87MG cell proliferation, adhesion, invasion, and vasculogenic mimicry formation potential and induce oxidative stress, apoptosis, and cell cycle arrest. We also found that the expression of proliferation, invasion, VM oxidative stress, apoptosis, and cell cycle-related gene and the activit...更多

Benzyl isothiocyanate has been shown to have inhibitory potential for human glioma U87MG cells; however, the effect and mechanism were not fully clear. In the present study, we found that BITC could inhibit U87MG cell proliferation, adhesion, invasion, and vasculogenic mimicry formation potential and induce oxidative stress, apoptosis, and cell cycle arrest. We also found that the expression of proliferation, invasion, VM oxidative stress, apoptosis, and cell cycle-related gene and the activity of tumor-related signaling pathways, including protein kinase C ζ and Akt/nuclear factor-kappa B pathways, were suppressed by BITC treatment. We also explored the anti-tumor potential of BITC in vivo, and we found that BITC also could regulate the expression of tumor-related gene and angiogenesis in nude mice model. Finally, we optimized the BITC construction targeting alkylglycerone phosphate synthase by computer-aided design, and the derivants also showed anti-tumor potential in vitro.收起

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