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作者

Wang, Jing Hu, Tao Sun, Dapeng Ding, Shujun Carr, Michael J. Xing, Weijia Li, Shixue Wang, Xianjun Shi, Weifeng

作者单位

Taishan Med Coll, Sch Publ Hlth, Tai An, Shandong, Peoples R China Shandong Prov Key Lab Communicable Dis Control &, Jinan, Shandong, Peoples R China Shandong Univ, Taishan Med Coll, Key Lab Etiol & Epidemiol Emerging Infect Dis, Tai An, Shandong, Peoples R China Shandong Univ, Sch Publ Hlth, Jinan, Shandong, Peoples R China Hokkaido Univ, Global Inst Collaborat Res & Educ GI CoRE, Global Stn Zoonosis Control, Sapporo, Hokkaido, Japan Shandong Ctr Dis Control & Prevent, Dept Viral Infect Dis Control & Prevent, Jinan, Shandong, Peoples R China Univ Coll Dublin, Natl Virus Reference Lab, Dublin 4, Ireland

刊名

SCIENTIFIC REPORTS

年份

2017

卷号

Vol.7

ISSN

2045-2322

摘要

In the past decade, hand, foot, and mouth disease has posed a serious threat to childhood health in China; however, no epidemiological data from large HFMD epidemics have been described since 2013. In the present study, we described the epidemiological patterns of HFMD in Shandong province during 2009-2016 from a large number of symptomatic cases , including >370,000 HFMD cases since 2013. Our results revealed that HFMD activity has remained at a high level and continued to cause annual epid...更多

In the past decade, hand, foot, and mouth disease has posed a serious threat to childhood health in China; however, no epidemiological data from large HFMD epidemics have been described since 2013. In the present study, we described the epidemiological patterns of HFMD in Shandong province during 2009-2016 from a large number of symptomatic cases , including >370,000 HFMD cases since 2013. Our results revealed that HFMD activity has remained at a high level and continued to cause annual epidemics in Shandong province from 2013 onwards. Although the incidence rate was significantly higher in urban areas than in rural areas, no significantly higher case-severity and case-fatality rates were found in urban areas. Furthermore, the seventeen cities of Shandong province could be classified into three distinct epidemiological groups according to the different peak times from southwest to northeast regions. Notably, a replacement of the predominant HFMD circulating agent was seen and non-EVA71/Coxsackievirus A16 enteroviruses became dominant in 2013 and 2015, causing approximately 30% of the severe cases. Our study sheds light on the latest epidemiological characteristics of HFMD in Shandong province and should prove helpful for the prevention and control of the disease in Shandong and elsewhere.收起

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