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作者

Wang Yan Dang Ningning Sun Pei Xia Jin Zhang Chunxue Pang Shuguang

作者单位

School of Medicine, Shandong University, Jinan 250013, Shandong Province, China|Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China|Department of Medicine, Taishan Medical University, Taian 271000, Shandong Province, China Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China|Department of Medicine, Taishan Medical University, Taian 271000, Shandong Province, China School of Medicine, Shandong University, Jinan 250013, Shandong Province, China|Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China|Department of Medicine, Taishan Medical University, Taian 271000, Shandong Province, China School of Medicine, Shandong University, Jinan 250013, Shandong Province, China|Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China|Department of Medicine, Taishan Medical University, Taian 271000, Shandong Province, China Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China|Department of Medicine, Taishan Medical University, Taian 271000, Shandong Province, China School of Medicine, Shandong University, Jinan 250013, Shandong Province, China|Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China|Department of Medicine, Taishan Medical University, Taian 271000, Shandong Province, China

刊名

Endocrine Journal

年份

2017

卷号

Vol.64 No.5

页码

543-552

关键词

Diabetes FGF21 FGFR1 β cell Visceral adipose

摘要

To understand metformin’s effects on fibroblast growth factors and fibroblast growth factor receptor 1 , we investigated circulating fibroblast growth factor-19 , FGF21 levels, and FGFR1 in type 2 diabetes mellitus . In addition, protein kinase B signaling pathway was detected to explain the possible mechanisms. T2DM was induced by feeding rats with high-fat diet for 11 weeks, followed by a low dose of streptozotocin . Control rats were fed on a normal chow; diabetic rats were fed on high-fa...更多

To understand metformin’s effects on fibroblast growth factors and fibroblast growth factor receptor 1 , we investigated circulating fibroblast growth factor-19 , FGF21 levels, and FGFR1 in type 2 diabetes mellitus . In addition, protein kinase B signaling pathway was detected to explain the possible mechanisms. T2DM was induced by feeding rats with high-fat diet for 11 weeks, followed by a low dose of streptozotocin . Control rats were fed on a normal chow; diabetic rats were fed on high-fat diet supplemented with or without metformin for 12 weeks . Biochemical parameters were detected at the end of 24th weeks. FGFR1 expression and protein kinase B phosphorylation in the pancreas and visceral adipose tissues were detected using either Western blot or immunohistochemistry . Serum FGF19 and FGF21 were measured using enzyme-linked immune sorbent assay . Metformin treated DM rats showed improved glucose, lipid and bile acid metabolism. Besides, significantly decreased FGF19 and increased FGF21 were observed in DM+METF rats. DM rats showed significantly increased FGFR1 both in the pancreas and visceral adipose tissues. While in DM+METF rats, FGFR1 was almost remained at a normal level in the pancreas and increased in the visceral adipose tissue compared to that in DM rats. Besides, metformin treatment restores Akt phosphorylation in both tissues. The altered glucose and lipid profiles by metformin treatment may be associated with the increased circulating FGF21 and tissue-specific expressions of FGFR1.收起

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