Palladium-Catalyzed Decarboxylative Csp-Csp Cross-Coupling Reactions: An Efficient Route for Synthesis of Azaisoflavone Derivatives

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作者: Xia, Chengcai Yang, Yong Wei, Zhenjiang Yu, Wenbo Liao, Hanxiao Shen, Chao Zhang, Pengfei

作者单位: Taishan Med Univ, Coll Pharm, Tai An 271016, Shandong, Peoples R China Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China Taishan Med Univ, Coll Pharm, Tai An 271016, Shandong, Peoples R China Zhejiang Univ Technol, Coll Pharm, Hangzhou 310014, Zhejiang, Peoples R China Zhejiang Univ Technol, Coll Pharm, Hangzhou 310014, Zhejiang, Peoples R China Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China

关键词: Azaisoflavone Decarboxylative coupling Ligand-free Aryl iodides Palladium-catalyzed

摘要: An efficient and step-economical ligand-free palladium-catalyzed decarboxylative functionalization of quinolinone-3-carboxylic acids has been well developed. Note that the reaction could proceed smoothly under an argon atmosphere at relatively low temperature by using Pd as the catalyst and Ag2CO3 as the oxidant. In this protocol, various functionalities were compatible under the reaction condition, and a series of biologically important azaisoflavone derivatives were obtained in moderate to hig...更多; An efficient and step-economical ligand-free palladium-catalyzed decarboxylative functionalization of quinolinone-3-carboxylic acids has been well developed. Note that the reaction could proceed smoothly under an argon atmosphere at relatively low temperature by using Pd as the catalyst and Ag2CO3 as the oxidant. In this protocol, various functionalities were compatible under the reaction condition, and a series of biologically important azaisoflavone derivatives were obtained in moderate to high yields.收起

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