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作者

Diao, Enjie Hou, Hanxue Chen, Bin Shan, Changpo Dong, Haizhou

作者单位

College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, PR China Animal Laboratory, Life Sciences Research Centre, Taishan Medical University, Taian 271000, PR China

刊名

Food & Chemical Toxicology

年份

2013

卷号

Vol.55

页码

519-525

ISSN

0278-6915

关键词

Aflatoxin B1 aflatoxin B1 ( AFB1 ) aflatoxin-contaminated peanuts ( ACPs ) alanine aminotransferase ( ALT ) albumin ( ALB ) blood urea nitrogen ( BUN ) body weight ( BW ) body weight gain ( BWG ) feed conversion efficiency ( FCE ) feed intake ( FI ) glucose ( GLU ) maleic dialdehyde ( MDA ) Safety assessment Subchronic toxicity experiment total cholesterol ( TC ) total protein ( TP ) total superoxide dismutase ( T-SOD ) triglycerides ( TG )

摘要

Ozonolysis efficiency of aflatoxin-contaminated peanuts was investigated, and the safety of ACPs untreated/treated by ozone was evaluated after 28-day intragastrically administration in male and female Wistar rats. 89.40% of aflatoxin B1 in peanuts was decomposed by ozone with a concentration of 50mg/L, flow rate of 5L/min for 60h. After 60h, the ozonolysis efficiency of AFB1 was not further improved. In the subchronic toxicity experiment, all rats did not have unusual changes in behavior, and...更多

Ozonolysis efficiency of aflatoxin-contaminated peanuts was investigated, and the safety of ACPs untreated/treated by ozone was evaluated after 28-day intragastrically administration in male and female Wistar rats. 89.40% of aflatoxin B1 in peanuts was decomposed by ozone with a concentration of 50mg/L, flow rate of 5L/min for 60h. After 60h, the ozonolysis efficiency of AFB1 was not further improved. In the subchronic toxicity experiment, all rats did not have unusual changes in behavior, and no signs of intoxication were observed except for several dead rats due to inappropriate gavage or anesthesia. The results of subchronic toxicity indicated that rats fed on ACPs alone had significantly decreased in body weight gain and feed conversion efficiency. Most serum biochemical indexes of rats had apparently changed compared with those in the negative control, and gender difference significantly affected most indexes of subchronic toxicity except for the ratios of organ to body weight and histopathological observation. Rats fed on ACPs treated by ozone showed significant beneficial health effects. All the results suggested that the deleterious effects of AFB1 could be highly reduced by ozone, and ozone itself did not show any toxic effects on animals in this processing.收起

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期刊