Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.Department of Anesthesiology, Zouping Hospital Affiliated to Taishan Medical University Zouping 256200, China.Department of Anesthesiology, Jinan Sixth People's Hospital Jinan 250021, China.Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.Department of Pharmacy, Taian Central Hospital Taian 271000, China.
刊名
Int J Clin Exp Med
年份
2015
卷号
Vol.8 No.6
摘要
OBJECTIVE: Peripheral nerve injury elicits an aversive state of spontaneous neuropathic pain, and up to now, the modulation of this concomitant aversive state remains a major therapeutic challenge. NMDA receptor subunits NR2B in the rACC are critically involved in the processing of this aversive state and then a strategy targeted at the NR2B subunit might be promising for modulation of the aversive state. Thus, in the present study, using negative reinforcement animal model to reveal spontaneous...更多
OBJECTIVE: Peripheral nerve injury elicits an aversive state of spontaneous neuropathic pain, and up to now, the modulation of this concomitant aversive state remains a major therapeutic challenge. NMDA receptor subunits NR2B in the rACC are critically involved in the processing of this aversive state and then a strategy targeted at the NR2B subunit might be promising for modulation of the aversive state. Thus, in the present study, using negative reinforcement animal model to reveal spontaneous pain, we investigated the effect of oral immunization with recombinant adenovirus serotype 5- mediated NR2B gene transfer on the modulation of the tonic pain. MATERIAL AND METHODS: Following oral administration of the rAd5/NR2B vaccine, NR2B-specific antibodies were induced in serum. And the humoral response was involved in the decreased expression of NR2B protein in the rACC. RESULTS: The present study demonstrated that CPP achieved by spinal administration of clonidine in spinal nerve ligation rats revealed the presence of aversive state of spontaneous neuropathic pain. Notably, the humoral autoimmune response blocked the CPP by spinal clonidine, suggesting the relief of the concomitant aversive of spontaneous neuropathic pain in the SNL rats. CONCLUSION: These data proved the feasibility of oral immunization with rAd5/NR2B for modulation of concomitant aversive of spontaneous neuropathic pain due to peripheral nerve injury.收起
发文期刊《Protective immunity of rAd5/NR2B vaccine against concomitant aversiveness of spontaneous neuropathic pain following spinal nerve ligation injury.》历年引证文献趋势图
