Antiphosphatidylserine/prothrombin antibodies as potential diagnostic markers and risk predictors of venous thrombosis and obstetric complications in antiphospholipid syndrome
Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Huangpu District, Shanghai, China Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Second Road, Huangpu District, Shanghai, China Department of Rheumatology and Immunology, Affiliated Hospital of Taishan Medical University, Shandong, China Werfen Medical Device Trading (Beijing) Co. Ltd., Beijing, China INOVA Diagnostics, Inc., San Diego, CA, United States Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
The aim of the study was to determine the prevalence and clinical associations of antiphosphatidylserine/prothrombin antibodies with thrombosis and pregnancy loss in Chinese patients with antiphospholipid syndrome and seronegative APS . One hundred and eighty six Chinese patients with APS , 48 with SNAPS, 176 disease controls and 90 healthy donors were examined. IgG and IgM aPS/PT, IgG/IgM/IgA anticardiolipin and IgG/IgM/IgA anti-β2-glycoprotein I antibodies were tested by ELISA. One hundre...更多
The aim of the study was to determine the prevalence and clinical associations of antiphosphatidylserine/prothrombin antibodies with thrombosis and pregnancy loss in Chinese patients with antiphospholipid syndrome and seronegative APS . One hundred and eighty six Chinese patients with APS , 48 with SNAPS, 176 disease controls and 90 healthy donors were examined. IgG and IgM aPS/PT, IgG/IgM/IgA anticardiolipin and IgG/IgM/IgA anti-β2-glycoprotein I antibodies were tested by ELISA. One hundred and sixty of APS patients were positive for at least one aPS/PT isotype. One hundred and thirty five were positive for IgG aPS/PT, 124/186 positive for IgM aPS/PT and 99 positive for both. Approximately half of the SNAPS patients were positive for IgG and/or IgM aPS/PT. Highly significant associations between IgG aPS/PT and venous thrombotic events and IgG/IgM aPS/PT and pregnancy loss were found. Levels of IgM aPS/PT were significantly different in APS patients with thrombotic manifestations and those with fetal loss . The association between IgG/IgM aPS/PT and lupus anticoagulant was highly significant . When both were positive, the OR for APS was 101.6. Notably, 91.95% of LAC-positive specimens were positive for IgG and/or IgM aPS/PT, suggesting aPS/PT is an effective option when LAC testing is not. Anti-PS/PT antibody assays demonstrated high diagnostic performance for Chinese patients with APS, detected some APS patients negative for criteria markers and may serve as potential risk predictors for venous thrombosis and obstetric complications.收起
发文期刊《Antiphosphatidylserine/prothrombin antibodies as potential diagnostic markers and risk predictors of venous thrombosis and obstetric complications in antiphospholipid syndrome》历年引证文献趋势图
