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作者

Jing, Lei Wang, Yun Zhao, Xiao-Min

作者单位

Department of Pharmocology, Taishan Medical University, Taian, 271000, China Department of Pharmacy, Boshan District Hospital of Zibo, Boshan, 255200, China Key Laboratory of Atherosclerosis in Universities of Shandong (Taishan Medical University), Taian, 271000, China Department of Diving Medicine, the Second Military Medical University, Shanghai, 200433, China Department of Pharmacy, Dongping County People's Hospital, Dongping, 271500, China

刊名

HEART LUNG AND CIRCULATION

年份

2015

卷号

Vol.24 No.6

页码

602-610

ISSN

1443-9506

关键词

Hydrogen Inflammation Isoproterenol Myocardial infarction Oxidative stress

摘要

Background Infusion with hydrogen gas-saturated saline has recently been reported to exert antioxidant and anti-inflammatory activity that may protect against organ damage induced by oxidative stress. Therefore because oxidative stress plays a significant role in the pathophysiology of myocardial infarction , the aim of our study was to investigate whether hydrogen-rich saline has cardioprotective effects against isoproterenol-induced MI in rats. Methods An acute MI model was induced in male Wis...更多

Background Infusion with hydrogen gas-saturated saline has recently been reported to exert antioxidant and anti-inflammatory activity that may protect against organ damage induced by oxidative stress. Therefore because oxidative stress plays a significant role in the pathophysiology of myocardial infarction , the aim of our study was to investigate whether hydrogen-rich saline has cardioprotective effects against isoproterenol-induced MI in rats. Methods An acute MI model was induced in male Wistar rats by subcutaneous injection of isoproterenol. Different doses of hydrogen-rich saline or Vitamin C were administered to the rats. Oxidative stress indices including levels... of myocardial marker enzymes, inflammatory cytokines, membrane-bound myocardial enzymes and histopathological changes were measured. Results Compared with those in isoproterenol-MI group, hydrogen-rich saline decreased malondialdehyde and 8-hydroxy-desoxyguanosine concentrations, enhanced superoxide dismutase and Na + -K + -ATPase activity, lowered Ca 2+ -ATPase activity and decreased interleukin-6 and tumour necrosis factor-α levels in the serum and/or cardiac tissue of rats. Hydrogen-rich saline pretreatment also diminished infarct size, improved left heart function, and ameliorated pathological changes of the left heart. Conclusion From these results, hydrogen-rich saline exerts cardiovascular protective effects against isoproterenol-induced MI at least in part via interactions which evoke antioxidant and anti-inflammatory activities.收起

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