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作者

Xiaowei Zheng Nimei Zeng Aili Wang Zhengbao Zhu Hao Peng Chongke Zhong Tan Xu Tian Xu Yanbo Peng Qunwei Li Zhong Ju Deqin Geng Yonghong Zhang Jiang He

作者单位

Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China Department of Neurology, Affiliated Hospital of North China University of Science and Technology, Hebei, China Department of Epidemiology, School of Public Health, Taishan Medical College, Shandong, China Department of Neurology, Kerqin District First People’s Hospital of Tongliao City, Inner Mongolia, China Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, China Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA

刊名

Neurological Research

ISSN

0161-6412;1743-1328

关键词

Stroke family history poor outcome

摘要

Background and aims : The association between family history of stroke and clinical outcomes after ischemic stroke remains unclear. Methods : A total of 3878 acute ischemic stroke patients from CATIS were included. The participants with ischemic stroke were divided into groups according to types of family history of stroke, stroke onset age and stroke subtypes. The primary outcome was a composite outcome of death and vascular events within 1 year after stroke. Multivariable Cox proportional h...更多

Background and aims : The association between family history of stroke and clinical outcomes after ischemic stroke remains unclear. Methods : A total of 3878 acute ischemic stroke patients from CATIS were included. The participants with ischemic stroke were divided into groups according to types of family history of stroke, stroke onset age and stroke subtypes. The primary outcome was a composite outcome of death and vascular events within 1 year after stroke. Multivariable Cox proportional hazard models were used to analyze the association between family history of stroke and other variables and clinical outcomes. Results : Among 3878 ischemic stroke patients, 708 had a history of stroke in their first-degree relatives and 399 experienced a composite outcome within 1 year after stroke. Overall family history was not associated with the primary outcome . However, the patients with maternal stroke history , stroke onset age<55 years with family history and thrombotic stroke in the patients with family history were associated with primary outcome, death and vascular events, respectively. Conclusion : This study suggests that maternal stroke history, age<55 years at stroke onset and thrombotic stroke in the patients with a family history are associated with poor outcomes after stroke. Further studies from other samples are needed to replicate our findings due to a reason for excluding some severe stroke patients in this study.收起

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