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作者

Peng Li Qingmin Li Yanqiang Zhang Shaojun Sun Shuntao Liu Zhaoxi Lu

作者单位

Department of Clinical Laboratory, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, China Department of Clinical Laboratory, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, China Department of Clinical Laboratory, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, China Department of Clinical Laboratory, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, China Department of Clinical Laboratory, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, China Department of Clinical Laboratory, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, China Corresponding author at: No. 67 Dongchang Road, Liaocheng, 252000, Shandong Province, China.

刊名

Biomedicine & Pharmacotherapy

年份

2018

卷号

Vol.104

页码

832-840

ISSN

0753-3322

关键词

miRNA Colorectal cancer Cell growth Apoptosis p38

摘要

The important role of miR-422a in tumor has been reported in several studies. Recent research discovered that the expression of miR-422a was significantly decreased in colorectal cancer tissues, providing miR-422a as a tumor suppressor in CRC. However, the concrete mechanism of miR-422a regulating CRC cell is still unclear. In this study, we demonstrated that miR-422a could inhibit CRC cell growth and promote cell apoptosis via in vitro analyses. Moreover, computational methods were adopted to i...更多

The important role of miR-422a in tumor has been reported in several studies. Recent research discovered that the expression of miR-422a was significantly decreased in colorectal cancer tissues, providing miR-422a as a tumor suppressor in CRC. However, the concrete mechanism of miR-422a regulating CRC cell is still unclear. In this study, we demonstrated that miR-422a could inhibit CRC cell growth and promote cell apoptosis via in vitro analyses. Moreover, computational methods were adopted to identify the targets of miR-422a. We found MAPKK6 was the direct target of miR-422a. Consequently, we further elucidated that miR-422a inhibited CRC cell growth and induced cell apoptosis by inhibiting p38/MAPK pathway. Besides that, we established the tumor xenograft model using nude mice and the inhibitory effects on tumor volumes and weights by miR-422a mimic transfection were also detected. Taken together, these findings demonstrated miR-422a exerted anti-cancer activities on CRC, which could be potentially used for CRC prognosis prediction and treatment.收起

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